CuATSM

更新时间：2024-01-02 11:06:30

CuATSM结构式	常用名	CuATSM	英文名	CuATSM
	CAS号	68341-09-3	分子量	321.91
	密度	N/A	沸点	N/A
	分子式	C₈H₁₄CuN₆S₂	熔点	N/A
	MSDS	美版	闪点	N/A

CuATSM用途

CuATSM是一种高效的自由基捕获抗氧化剂(RTA)和(磷酸)脂质过氧化抑制剂,因此具有抑制铁下垂的能力。

中文名	[[2,2′-(1,2-二甲基-1,2-乙二亚甲基)双[N-甲基肼甲硫代酰胺基]]]铜
英文名	0YDK1H9L3A
英文别名	更多

描述	CuATSM是一种高效的自由基捕获抗氧化剂(RTA)和(磷酸)脂质过氧化抑制剂,因此具有抑制铁下垂的能力。
相关类别	信号通路 >> 细胞凋亡 >> Ferroptosis 研究领域 >> 神经疾病
参考文献	[1]. Zilka O, et al. Radical-Trapping Antioxidant Activity of Copper and Nickel Bis(Thiosemicarbazone) Complexes Underlies Their Potency as Inhibitors of Ferroptotic Cell Death. J Am Chem Soc. 2021 Nov 17;143(45):19043-19057.

分子式	C₈H₁₄CuN₆S₂
分子量	321.91
精确质量	321.001740
外观性状	powder
储存条件	2-8°C
水溶解性	DMSO: soluble10mg/mL, clear

危险品运输编码	NONH for all modes of transport
WGK德国	3

Zn II(atsm) is protective in amyotrophic lateral sclerosis model mice via a copper delivery mechanism.

Neurobiol. Dis. 81 , 20-4, (2015)

Mutations in the metalloprotein Cu,Zn-superoxide dismutase (SOD1) cause approximately 20% of familial cases of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease for which effectiv...

Oral treatment with Cu(II)(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis.

J. Neurosci. 34(23) , 8021-31, (2014)

Mutations in the metallo-protein Cu/Zn-superoxide dismutase (SOD1) cause amyotrophic lateral sclerosis (ALS) in humans and an expression level-dependent phenotype in transgenic rodents. We show that o...

Therapeutic effects of CuII(atsm) in the SOD1-G37R mouse model of amyotrophic lateral sclerosis.

Amyotroph. Lateral Scler. Frontotemporal Degener. 14(7-8) , 586-90, (2013)

Our objective was to assess the copper(II) complex of diacetylbis(4-methylthiosemicarbazone) [Cu(II)(atsm)] for its preclinical potential as a novel therapeutic for ALS. Experimental paradigms used we...

Copper(2+) (2E,2'E)-2,2'-[(2E,3E)-2,3-butanediylidene]bis(N-methylhydrazinecarbimidothioate)

Hydrazinecarbothioamide, 2,2'-[(1E,2E)-1,2-dimethyl-1,2-ethanediylidene]bis[N-methyl-, copper(2+) salt, (2E,2'E)- (1:1)

ATSM CU-64

0YDK1H9L3A

Cu-ASTM