顺式PPDA

• 常用名: 顺式PPDA
• 英文名: PPDA
• CAS号: 684283-16-7
• 分子量: 756.756
• 密度: N/A
• 沸点: N/A
• 分子式: C₄₂H₃₆N₄O₁₀
• 熔点: N/A
• 闪点: N/A

顺式PPDA用途

PPDA是一种亚型选择性NMDA受体拮抗剂,优先与含有NR2C/NR2D的受体结合[1]。

顺式PPDA名称

• 中文名: 顺式PPDA
• 英文名: (2R,3S)-1-(2-Phenanthrylcarbonyl)-2,3-piperazinedicarboxylic acid-(2S,3R)-1-(2-phenanthrylcarbonyl)-2,3-piperazinedicarboxylic acid (1:1)

顺式PPDA生物活性

• 描述: PPDA是一种亚型选择性NMDA受体拮抗剂,优先与含有NR2C/NR2D的受体结合[1]。
• 相关类别:
  信号通路 >> 神经信号通路 >> iGluR
  研究领域 >> 神经疾病
  信号通路 >> 跨膜转运 >> iGluR
• 参考文献:

  [1]. Kinarsky L, et al. Identification of subunit- and antagonist-specific amino acid residues in the N-Methyl-D-aspartate receptor glutamate-binding pocket. J Pharmacol Exp Ther. 2005 Jun;313(3):1066-74.

顺式PPDA物理化学性质

• 分子式: C₄₂H₃₆N₄O₁₀
• 分子量: 756.756
• 精确质量: 756.243164
• InChIKey: IWWXIZOMXGOTPP-MSOLQXFVSA-N
• SMILES: O=C(O)C1NCCN(C(=O)c2ccc3c(ccc4ccccc43)c2)C1C(=O)O

顺式PPDA靶点实验

查看更多实验

实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-p1-antagonist

实验名称：Cell Viability qHTS for small molecule stabilizers of the endoplasmic reticulum resid... 来源：NCGC 靶标：N/A External Id：SERCaMPGluc-f3-cellviability-42h

实验名称：Confirmatory qHTS for small molecule stabilizers of the endoplasmic reticulum residen... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-f1_f3-antagonist

实验名称：Counterscreen qHTS for small molecule stabilizers of the endoplasmic reticulum reside... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-f3-counterscreen-19h

实验名称：qHTS for Inhibitors of Polymerase Kappa 来源：NCGC 靶标：DNA polymerase kappa [Homo sapiens] External Id：PolK100

实验名称：Antagonist activity rat recombinant GluN1/GluN2D receptor expressed in Xenopus laevis... 来源：ChEMBL 靶标：Glutamate receptor ionotropic, NMDA 2D External Id：CHEMBL1954480

实验名称：Antagonist activity at human recombinant GluK1 receptor expressed in human HEK293 cel... 来源：ChEMBL 靶标：Glutamate receptor ionotropic, kainate 1 External Id：CHEMBL1954485

实验名称：High Throughput Screening for Foot and Mouth Disease Virus Antivirals 来源：NCGC 靶标：N/A External Id：StopGo1

实验名称：Antagonist activity at human recombinant GluK2 receptor expressed in human HEK293 cel... 来源：ChEMBL 靶标：Glutamate receptor ionotropic, kainate 2 External Id：CHEMBL1954486

实验名称：Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus lae... 来源：ChEMBL 靶标：Glutamate receptor ionotropic, NMDA 2A External Id：CHEMBL1954477

共14条，当前第1页，共2页

1

2

顺式PPDA英文别名

• 2,3-Piperazinedicarboxylic acid, 1-(2-phenanthrenylcarbonyl)-, (2R,3S)-, compd. with (2S,3R)-1-(2-phenanthrenylcarbonyl)-2,3-piperazinedicarboxylic acid (1:1)
• (2R,3S)-1-(2-Phenanthrylcarbonyl)-2,3-piperazinedicarboxylic acid - (2S,3R)-1-(2-phenanthrylcarbonyl)-2,3-piperazinedicarboxylic acid (1:1)