氨己烯酸

更新时间：2025-08-25 06:41:48

氨己烯酸结构式	常用名	氨己烯酸	英文名	Vigabatrin
	CAS号	68506-86-5	分子量	129.157
	密度	1.1±0.1 g/cm3	沸点	277.7±28.0 °C at 760 mmHg
	分子式	C₆H₁₁NO₂	熔点	N/A
	MSDS	中文版美版	闪点	121.7±24.0 °C

氨己烯酸用途

Vigabatrin盐酸盐(γ-Vinyl-GABA; Sabril)是GABA的结构类似物,能不可逆地抑制GABA氨基转移酶对GABA的分解代谢。

中文名	氨己烯酸
英文名	Vigabatrin
中文别名	4-氨基-5-己烯酸
英文别名	更多

描述	Vigabatrin盐酸盐(γ-Vinyl-GABA; Sabril)是GABA的结构类似物,能不可逆地抑制GABA氨基转移酶对GABA的分解代谢。
相关类别	信号通路 >> 跨膜转运 >> GABA受体信号通路 >> 神经信号通路 >> GABA受体研究领域 >> 神经疾病
参考文献	[1]. Broeer, et al. Vigabatrin for focal drug delivery in epilepsy: Bilateral microinfusion into the subthalamic nucleus is more effective than intranigral or systemic administration in a rat seizure model. Neurobiology of Disease (2012), 46(2), 362-376. [2]. Gaily, Eija Vigabatrin monotherapy for infantile spasms. Expert Review of Neurotherapeutics (2012), 12(3), 275-286. [3]. Russo, et al. Vigabatrin has antiepileptogenic and antidepressant effects in an animal model of epilepsy and depression comorbidity. Behavioural Brain Research (2011), 225(1), 373-376. [4]. Vigabatrin

描述

Vigabatrin盐酸盐(γ-Vinyl-GABA; Sabril)是GABA的结构类似物,能不可逆地抑制GABA氨基转移酶对GABA的分解代谢。

相关类别

信号通路 >> 跨膜转运 >> GABA受体

信号通路 >> 神经信号通路 >> GABA受体

研究领域 >> 神经疾病

参考文献

[1]. Broeer, et al. Vigabatrin for focal drug delivery in epilepsy: Bilateral microinfusion into the subthalamic nucleus is more effective than intranigral or systemic administration in a rat seizure model. Neurobiology of Disease (2012), 46(2), 362-376.

[2]. Gaily, Eija Vigabatrin monotherapy for infantile spasms. Expert Review of Neurotherapeutics (2012), 12(3), 275-286.

[3]. Russo, et al. Vigabatrin has antiepileptogenic and antidepressant effects in an animal model of epilepsy and depression comorbidity. Behavioural Brain Research (2011), 225(1), 373-376.

[4]. Vigabatrin

密度	1.1±0.1 g/cm3
沸点	277.7±28.0 °C at 760 mmHg
分子式	C₆H₁₁NO₂
分子量	129.157
闪点	121.7±24.0 °C
精确质量	129.078979
PSA	63.32000
LogP	-0.10
InChIKey	PJDFLNIOAUIZSL-UHFFFAOYSA-N
SMILES	C=CC(N)CCC(=O)O
蒸汽压	0.0±1.2 mmHg at 25°C
折射率	1.483
储存条件	2-8℃

个人防护装备	dust mask type N95 (US);Eyeshields;Gloves
危险品运输编码	NONH for all modes of transport
RTECS号	MP7745000

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Chem. Res. Toxicol. 23 , 171-83, (2010)

Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

J. Sci. Ind. Res. 65(10) , 808, (2006)

Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

实验名称：Ratio of kinact to that of KI.
来源：ChEMBL
靶标：N/A
External Id：CHEMBL846525

实验名称：Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay
来源：ChEMBL
靶标：N/A
External Id：CHEMBL1266185

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
来源：NCGC
External Id：SNCA-p-activity-luciferase

实验名称：Dissociation constant pKa was reported.
来源：ChEMBL
靶标：N/A
External Id：CHEMBL632406

实验名称：Dicer-mediated maturation of pre-microRNA
来源：Center for Chemical Genomics, University of Michigan
靶标：N/A
External Id：TargetID_659_CEMA

实验名称：Dose required to produce a 50% reduction in general motor activity after injection in...
来源：ChEMBL
靶标：Mus musculus
External Id：CHEMBL737529

实验名称：qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity
来源：NCGC
External Id：HERG01

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac...
来源：ChEMBL
靶标：Severe acute respiratory syndrome coronavirus 2
External Id：CHEMBL4303805

实验名称：qHTS for Inhibitors of ATXN expression: Validation of Cytotoxic Assay
来源：NCGC
靶标：N/A
External Id：SCA2002

实验名称：Contractile Force Screening of Prestwick Library for asthma drug discovery
来源：24015
靶标：N/A
External Id：HSPH_Screening_CFS_001

共330条，当前第1页，共33页