ARM-1

• 常用名: ARM-1
• 英文名: ARM-1
• CAS号: 68729-05-5
• 分子量: 266.361
• 密度: 1.2±0.1 g/cm3
• 沸点: 462.7±24.0 °C at 760 mmHg
• 分子式: C₁₆H₁₄N₂S
• 熔点: N/A
• 闪点: 233.6±22.9 °C

ARM-1用途

ARM1(4BSA)是一种有效的氨基肽酶和环氧化物水解酶抑制剂。ARM1显示出IC50为7.61µM的氨肽酶抑制活性和IC50为12.4µM的环氧化物水解酶抑制活性【1】。

ARM-1名称

• 英文名: ARM-1

ARM-1生物活性

• 描述: ARM1(4BSA)是一种有效的氨基肽酶和环氧化物水解酶抑制剂。ARM1显示出IC50为7.61µM的氨肽酶抑制活性和IC50为12.4µM的环氧化物水解酶抑制活性【1】。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> 氨肽酶
• 参考文献:

  [1]. El-Naggar MH, et al. Synthesis, docking, cytotoxicity, and LTA4H inhibitory activity of new gingerol derivatives as potential colorectal cancer therapy. Bioorg Med Chem. 2017;25(3):1277-1285.

ARM-1物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 462.7±24.0 °C at 760 mmHg
• 分子式: C₁₆H₁₄N₂S
• 分子量: 266.361
• 闪点: 233.6±22.9 °C
• 精确质量: 266.087769
• LogP: 4.13
• InChIKey: XYDVHKCVOMGRSY-UHFFFAOYSA-N
• SMILES: Nc1nc(-c2ccc(Cc3ccccc3)cc2)cs1
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.660
• 储存条件: 室温

ARM-1靶点实验

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实验名称：Binding affinity to human C-terminal His6-tagged/N-terminal T7 gene leader sequence-t... 来源：ChEMBL 靶标：Leukotriene A-4 hydrolase External Id：CHEMBL3861347

实验名称：Experimentally measured binding affinity data (Ki) for protein-ligand complexes deriv... 来源：Shanghai Institute of Organic Chemistry 靶标：N/A External Id：PDBbind-Ki for protein-ligand complexes

实验名称：Binding affinity to human C-terminal His6-tagged/N-terminal T7 gene leader sequence-t... 来源：ChEMBL 靶标：Leukotriene A-4 hydrolase External Id：CHEMBL3861348

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Activation of N-terminal (His)6 and Xpress-tagged LTA4H (unknown origin) expressed in... 来源：ChEMBL 靶标：Leukotriene A-4 hydrolase External Id：CHEMBL4417214

实验名称：Activation of N-terminal (His)6 and Xpress-tagged LTA4H (unknown origin) expressed in... 来源：ChEMBL 靶标：Leukotriene A-4 hydrolase External Id：CHEMBL4417215

实验名称：Activation of N-terminal (His)6 and Xpress-tagged LTA4H (unknown origin) expressed in... 来源：ChEMBL 靶标：Leukotriene A-4 hydrolase External Id：CHEMBL4417216

实验名称：Activation of N-terminal (His)6 and Xpress-tagged LTA4H (unknown origin) expressed in... 来源：ChEMBL 靶标：Leukotriene A-4 hydrolase External Id：CHEMBL4417217

实验名称：Activation of N-terminal (His)6 and Xpress-tagged LTA4H (unknown origin) expressed in... 来源：ChEMBL 靶标：Leukotriene A-4 hydrolase External Id：CHEMBL4417218

实验名称：Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3877048

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ARM-1英文别名

• 4-(4-Benzylphenyl)-1,3-thiazol-2-amine