PDM 2

• 常用名: PDM 2
• 英文名: PDM 2
• CAS号: 688348-25-6
• 分子量: 283.580
• 密度: 1.4±0.1 g/cm3
• 沸点: 394.2±42.0 °C at 760 mmHg
• 分子式: C₁₄H₉Cl₃
• 熔点: N/A
• 闪点: 276.5±23.5 °C

PDM 2用途

PDM2 是一种选择性的高亲和力芳烃受体 (AhR) 拮抗剂,Ki 为 1.2±0.4 nM。

PDM 2名称

• 中文名: PDM 2
• 英文名: 1,3-dichloro-5-[2-(4-chlorophenyl)ethenyl]benzene

PDM 2生物活性

• 描述: PDM2 是一种选择性的高亲和力芳烃受体 (AhR) 拮抗剂,Ki 为 1.2±0.4 nM。
• 相关类别:
  信号通路 >> 免疫及炎症 >> 芳基烃受体
  研究领域 >> 炎症/免疫
• 靶点实验:

  Ki: 1.2±0.4 nM(AhR)[1]

• 体外研究: PDM2(化合物4b)对于AhR表现出1.2±0.4nM的Ki并且对雌激素受体(ER)没有亲和力,证实用氯取代羟基消除了对ER的结合并且显着增加了对AhR的亲和力[1]。
• 参考文献:

  [1]. de Medina P, et al. Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. J Med Chem. 2005 Jan 13;48(1):287-91.

PDM 2物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 394.2±42.0 °C at 760 mmHg
• 分子式: C₁₄H₉Cl₃
• 分子量: 283.580
• 闪点: 276.5±23.5 °C
• 精确质量: 281.976990
• LogP: 6.58
• InChIKey: JMYNPQVCVQVODQ-OWOJBTEDSA-N
• SMILES: Clc1ccc(C=Cc2cc(Cl)cc(Cl)c2)cc1
• 蒸汽压: 0.0±0.9 mmHg at 25°C
• 折射率: 1.675
• 储存条件: 2-8℃

PDM 2靶点实验

查看更多实验

实验名称：Tested for cytotoxicity towards A549 cell line (human lung carcinoma); Not active 来源：ChEMBL 靶标：A549 External Id：CHEMBL825830

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：Tested for cytotoxicity towards T47D cell line (human breast cancer); Not active 来源：ChEMBL 靶标：T47D External Id：CHEMBL826646

实验名称：Binding affinity to aryl hydrocarbon receptor (unknown origin) 来源：ChEMBL 靶标：Aryl hydrocarbon receptor External Id：CHEMBL3055293

实验名称：Tested for cytotoxicity towards MCF-7 cell line (human breast cancer); Not active 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL825831

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：Stabilization of p53 in human papillomavirus-positive cells 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Cellular tumor antigen p53 External Id：HMS1485

实验名称：Discovering small molecule activators of G protein-gated inwardly-rectifying potassiu... 来源：15621 靶标：G protein-activated inward rectifier potassium channel 2 External Id：VANDERBILT_HTS_GIRK2_MPD

实验名称：Inhibition of human TRPA1 expressed in HEK293 cells assessed as decrease in AITC-indu... 来源：ChEMBL 靶标：Transient receptor potential cation channel subfamily A member 1 External Id：CHEMBL4022612

实验名称：In Vitro Binding Assay from Article 10.1021/jm0498194: "Synthesis and biological prop... 来源：BindingDB 靶标：N/A External Id：BindingDB_2736_1

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PDM 2英文别名

• 1,3-Dichloro-5-[(E)-2-(4-chlorophenyl)vinyl]benzene
• 1,3-dichloro-5-[(E)-2-(4-chlorophenyl)ethenyl]benzene
• PDM 2