SKF 91488 dihydrochloride

• 常用名: SKF 91488 dihydrochloride
• 英文名: SKF 91488 dihydrochloride
• CAS号: 68941-21-9
• 分子量: 248.22
• 密度: N/A
• 沸点: N/A
• 分子式: C₇H₁₉Cl₂N₃S
• 熔点: N/A
• 闪点: N/A

SKF 91488 dihydrochloride用途

SKF 91488 dihydrochloride (Homodimaprit) 是一种有效的非竞争性组胺 N-甲基转移酶抑制剂,Ki 值为 0.9 microM。SKF 91488 dihydrochloride 抑制小鼠体内标记组胺的甲基化。

SKF 91488 dihydrochloride名称

• 英文名: Homodimaprit dihydrochloride

SKF 91488 dihydrochloride生物活性

• 描述: SKF 91488 dihydrochloride (Homodimaprit) 是一种有效的非竞争性组胺 N-甲基转移酶抑制剂,Ki 值为 0.9 microM。SKF 91488 dihydrochloride 抑制小鼠体内标记组胺的甲基化。
• 相关类别:
  信号通路 >> 表观遗传学 >> 组蛋白甲基转移酶
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Beaven MA, et, al. Inhibition of histamine methylation in vivo by the dimaprit analog, SKF Compound 91488. Agents Actions. 1979 Dec;9(5-6):455-60.

SKF 91488 dihydrochloride物理化学性质

• 分子式: C₇H₁₉Cl₂N₃S
• 分子量: 248.22
• 精确质量: 211.09100
• PSA: 78.41000
• LogP: 2.55690
• InChIKey: NPLHSMBWWIIWAQ-UHFFFAOYSA-N
• SMILES: CN(C)CCCCSC(=N)N.Cl.Cl

SKF 91488 dihydrochloride靶点实验

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实验名称：Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL1266185

实验名称：qHTS for Inhibitors of Polymerase Iota 来源：NCGC 靶标：DNA polymerase iota [Homo sapiens] External Id：PolI100

实验名称：qHTS for Inhibitors of Polymerase Eta 来源：NCGC 靶标：DNA polymerase eta [Homo sapiens] External Id：PolE100

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Small-molecule inhibitors of ST2 (IL1RL1) 来源：20881 靶标：interleukin-1 receptor-like 1 isoform [homo sapiens] External Id：ST2_IL33_Inhibitors_Primary_Screening_77700

实验名称：qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity 来源：NCGC External Id：HERG01

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1):... 来源：NCGC 靶标：thioredoxin reductase [Rattus norvegicus] External Id：TRXR100

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

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SKF 91488 dihydrochloride英文别名

• S-(4-dimethylamino-butyl)-isothiourea, dihydrochloride
• S-(4-Dimethylamino-butyl)-isothioharnstoff, Dihydrochlorid
• S-[4-(dimethylamino)butyl]isothiourea dihydrochloride