17-PA

• 常用名: 17-PA
• 英文名: 17-PA
• CAS号: 694438-95-4
• 分子量: 430.534
• 密度: 1.3±0.1 g/cm3
• 沸点: 599.7±50.0 °C at 760 mmHg
• 分子式: C₂₅H₃₄O₆
• 熔点: N/A
• 闪点: 201.8±23.6 °C

17-PA用途

17-PA是神经甾体增强和GABAA受体直接门控的选择性拮抗剂【1】。

17-PA名称

• 英文名: 17-Phenyl-(3α,5α)-androst-16-en-3-ol

17-PA生物活性

• 描述: 17-PA是神经甾体增强和GABAA受体直接门控的选择性拮抗剂【1】。
• 相关类别:
  信号通路 >> 跨膜转运 >> GABA受体
  研究领域 >> 神经疾病
  信号通路 >> 神经信号通路 >> GABA受体
• 参考文献:

  [1]. Mennerick S, et al. Selective antagonism of 5alpha-reduced neurosteroid effects at GABA(A) receptors. Mol Pharmacol. 2004 May;65(5):1191-7.

17-PA物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 599.7±50.0 °C at 760 mmHg
• 分子式: C₂₅H₃₄O₆
• 分子量: 430.534
• 闪点: 201.8±23.6 °C
• 精确质量: 430.235535
• PSA: 20.23000
• LogP: 3.14
• InChIKey: SINAMTXBCYKFDL-WBJZGETLSA-N
• SMILES: CC12CCC3C(CCC4CC(O)CCC43C)C1CC=C2c1ccccc1
• 蒸汽压: 0.0±3.9 mmHg at 25°C
• 折射率: 1.592

17-PA靶点实验

查看更多实验

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

实验名称：Enzymatic assay of human HDAC6 with custom peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808150

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

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17-PA英文别名

• Budesonide
• Respules
• Spirocort
• Bidien
• Budesonide,(11β,16α)-16,17-[Butylidenebis(oxy)]-11,21-dihydroxypregna-1,4-diene-3,20-dione
• S-1320
• 16,17-Butylidenebis(oxy)-11,21-dihydroxypregna-1,4-diene-3,20-dione
• Budeson
• Micronyl
• Pulmicort
• 17-PA
• ENTOCORT
• Rhinocort
• (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-6b-Glycoloyl-5-hydroxy-4a,6a-dimethyl-8-propyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
• PREFERID
• 2-BFI hydrochloride