甲基卡枯醇

• 常用名: 甲基卡枯醇
• 英文名: Methyl Kakuol
• CAS号: 70342-29-9
• 分子量: 208.21100
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₁H₁₂O₄
• 熔点: N/A
• 闪点: N/A

甲基卡枯醇用途

甲基咔唑表现出对抗TRPA1的激动活性,EC50为0.27µM[1]。

甲基卡枯醇名称

• 中文名: 甲基卡枯醇
• 英文名: 1-(6-methoxy-1,3-benzodioxol-5-yl)propan-1-one

甲基卡枯醇生物活性

• 描述: 甲基咔唑表现出对抗TRPA1的激动活性,EC50为0.27µM[1]。
• 相关类别:
  信号通路 >> 跨膜转运 >> TRP频道
  研究领域 >> 神经疾病
• 靶点实验:

  TRPA1

• 体内研究: 2 g/kg剂量(分别含有1156µg/kg、294µg/kg、452µg/kg、852µg/kg细辛林、芝麻素、甲基卡库醇和酰胺a)下甲基卡库醇的最大浓度(Cmax)为98.2 ng/mL[1]。
• 参考文献:

  [1]. Takashi Matsumoto, et al. In Vivo Pharmacokinetic Analysis Utilizing Non-Targeted and Targeted Mass Spectrometry and In Vitro Assay against Transient Receptor Potential Channels of Maobushisaishinto and Its Constituent Asiasari Radix. Molecules. 2020 Sep 18;25(18):4283.

甲基卡枯醇物理化学性质

• 分子式: C₁₁H₁₂O₄
• 分子量: 208.21100
• 精确质量: 208.07400
• PSA: 44.76000
• LogP: 2.01660
• InChIKey: XPHIRVUYIBXETG-UHFFFAOYSA-N
• SMILES: CCC(=O)c1cc2c(cc1OC)OCO2
• 储存条件: 2-8°C

甲基卡枯醇靶点实验

查看更多实验

实验名称：Anti-parkinson's disease activity in human ONS cells assessed as early endosome marke... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5365779

实验名称：Anti-parkinson's disease activity in human ONS cells assessed as early endosome marke... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5365780

实验名称：Anti-parkinson's disease activity in human ONS cells assessed as lysosome marker inte... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5365777

实验名称：Anti-parkinson's disease activity in human ONS cells assessed as lysosome marker inte... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5365778

实验名称：Anti-parkinson's disease activity in human ONS cells assessed as lysosome marker inte... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5365776

实验名称：Anti-parkinson's disease activity in human ONS cells assessed as negative mitochondri... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5365769

实验名称：Anti-parkinson's disease activity in human ONS cells assessed as negative mitochondri... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5365767

实验名称：Anti-parkinson's disease activity in human ONS cells assessed as negative mitochondri... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5365768

实验名称：Anti-parkinson's disease activity in human ONS cells assessed as early endosome marke... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5365781

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甲基卡枯醇英文别名

• 1-Propanone,1-(6-methoxy-1,3-benzodioxol-5-yl)
• Methyl kakuol