土霉素钙

• 常用名: 土霉素钙
• 英文名: Calcium oxytetracycline
• CAS号: 7179-50-2
• 分子量: 498.49600
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₂₂CaN₂O₉
• 熔点: N/A
• 闪点: N/A

土霉素钙用途

土霉素钙是一种四环素类抗生素。土霉素钙能有效抑制革兰氏阴性和革兰氏阳性细菌。土霉素钙是一种蛋白质合成抑制剂,可阻止氨基ACIL tRNA与复杂m-核糖体RNA的结合。土霉素钙还具有抗HSV-1活性[1][2][3]。

土霉素钙名称

• 中文名: 土霉素钙
• 英文名: calcium,(5S,5aR,6S,6aR,7S,10aR)-9-carbamoyl-7-(dimethylamino)-5,6,10,10a-tetrahydroxy-5-methyl-8,11-dioxo-5a,6,6a,7-tetrahydrotetracene-1,12-diolate

土霉素钙生物活性

• 描述: 土霉素钙是一种四环素类抗生素。土霉素钙能有效抑制革兰氏阴性和革兰氏阳性细菌。土霉素钙是一种蛋白质合成抑制剂,可阻止氨基ACIL tRNA与复杂m-核糖体RNA的结合。土霉素钙还具有抗HSV-1活性[1][2][3]。
• 相关类别:
  信号通路 >> 抗感染 >> HSV
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 体外研究: 土霉素钙是细菌芳香聚酮家族的重要成员,是一类结构多样的天然产物。土霉素钙由II型聚酮类合酶合成,该合酶通过丙二酰辅酶a扩链剂单元的连续脱羧缩合生成聚β-酮主链,然后通过环化酶、加氧酶、转移酶和其他裁剪酶进行修饰[2]。
• 体内研究: 给药治疗剂量的土霉素(82.8 mg/kg体重至1%体重/天)钙10天的效果具有物种特异性。土霉素钙增加了莫龙虎鱼的相对肝脏重量,增加了点状黄疸中CYP3A4的酶活性,增加了尼罗罗非鱼中CYP3A4的蛋白表达,并耗尽了后者中的肝脏CYP3A4[1]。对于土霉素钙,在肌肉和牛奶中的限量为100μg/kg,在鸡蛋中为200μg/千克,在肝脏中为300μg/kg,在肾脏中为600μg/公斤。将土霉素钙作为药物饲料施用于鱼类,浓度范围为35至75 mg a.i kg-1生物量day-1,持续7-14天[1]。
• 参考文献:

  [1]. Elia, A.C., et al., Transferability of oxytetracycline (OTC) from feed to carp muscle and evaluation of the antibiotic effects on antioxidant systems in liver and kidney. Fish Physiol Biochem, 2014.

  [2]. Pickens LB, et al. Oxytetracycline biosynthesis. J Biol Chem. 2010 Sep 3;285(36):27509-15.

  [3]. Oguz Guvenmez, et al. A New Treatment Method for Herpes Simplex Virus Type 1-related Skin Lesions. Scientific & Academic. 2019; 8(1): 6-8.

土霉素钙物理化学性质

• 分子式: C₂₂H₂₂CaN₂O₉
• 分子量: 498.49600
• 精确质量: 498.09500
• PSA: 208.50000
• LogP: 0.06020
• InChIKey: QMRSMEWUOGCGKH-IFLJXUKPSA-N
• SMILES: CN(C)C1C(=O)C(C(N)=O)=C(O)C2(O)C(=O)C3=C(O)c4c(O)cccc4C(C)(O)C3C(O)C12.[Ca]

土霉素钙靶点实验

查看更多实验

实验名称：Fluorescence-based counterscreen for orexin 1 receptor (OX1R) antagonists: cell-based... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：CHOK1_ANT_FLUO8_1536_1X%INH CSRUN

实验名称：qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2 来源：NCGC 靶标：eyes absent homolog 2 isoform a [Homo sapiens] External Id：EYA2477

实验名称：Absorbance-based primary biochemical high throughput screening assay to identify acti... 来源：The Scripps Research Institute Molecular Screening Center 靶标：caspase-3 preproprotein [Homo sapiens] External Id：PROCASPASE3_ACT_EPIABS_1536_1X%ACT PRUN

实验名称：Primary cell-based high-throughput screening for identification of compounds that inh... 来源：Johns Hopkins Ion Channel Center 靶标：anoctamin-1 isoform 1 [Mus musculus] External Id：JHICC_CaCC_Inh_Primary

实验名称：Primary cell-based high-throughput screening for identification of compounds that act... 来源：Johns Hopkins Ion Channel Center 靶标：MAS-related GPR member X1 [Homo sapiens] External Id：JHICC_MrgX1_Agonist_Primary

实验名称：Primary cell-based high-throughput screening for identification of compounds that all... 来源：Johns Hopkins Ion Channel Center 靶标：MAS-related GPR member X1 [Homo sapiens] External Id：JHICC_MrgX1_AlloAgonist_Primary

实验名称：Primary cell-based high-throughput screening for identification of compounds that ant... 来源：Johns Hopkins Ion Channel Center 靶标：MAS-related GPR member X1 [Homo sapiens] External Id：JHICC_MrgX1_Antagonist_Primary

实验名称：Counterscreen for procaspase-3 activators: absorbance-based primary biochemical high ... 来源：The Scripps Research Institute Molecular Screening Center 靶标：caspase 7, apoptosis-related cysteine peptidase [Homo sapiens] External Id：PROCASPASE7_ACT_EPIABS_1536_1X%ACT CSRUN

实验名称：Fluorescence polarization-based primary biochemical high throughput screening assay t... 来源：The Scripps Research Institute Molecular Screening Center 靶标：platelet-activating factor acetylhydrolase precursor [Homo sapiens] External Id：PPAFAH_INH_FP_1536_1X%INH PRUN

实验名称：qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme ... 来源：NCGC 靶标：Luciferase [Photinus pyralis] External Id：FLUC100

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土霉素钙英文别名

• C22H22N2O9.Ca
• Oxytetracycline calcium
• Calcium oxytetracycline
• EINECS 230-540-4
• 5 Oxytetracycline calcium
• Oxytetracycline,Calcium (1:1) Salt