PTP1B-IN-14

• 常用名: PTP1B-IN-14
• 英文名: PTP1B-IN-14
• CAS号: 724451-35-8
• 分子量: 589.73
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₇H₁₉N₅O₃S₄
• 熔点: N/A
• 闪点: N/A

PTP1B-IN-14用途

PTP1B-IN-14是一种选择性PTP1B抑制剂(IC50=0.72μM),靶向变构位点。

PTP1B-IN-14名称

• 英文名: PTP1B-IN-14

PTP1B-IN-14生物活性

• 描述: PTP1B-IN-14是一种选择性PTP1B抑制剂(IC50=0.72μM),靶向变构位点。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 磷酸酶
  研究领域 >> 其他
• 参考文献:

  [1]. Yang Y, et al. Integrated Approach to Identify Selective PTP1B Inhibitors Targeting the Allosteric Site. J Chem Inf Model. 2021 Sep 27;61(9):4720-4732.

PTP1B-IN-14物理化学性质

• 分子式: C₂₇H₁₉N₅O₃S₄
• 分子量: 589.73
• InChIKey: YXXHMCHMAVOSQR-UHFFFAOYSA-N
• SMILES: Cc1cccc(CSc2nnc(NC(=O)CSc3nc4ccc(N5C(=O)c6ccccc6C5=O)cc4s3)s2)c1

PTP1B-IN-14靶点实验

查看更多实验

实验名称：Inhibition of PTP1B (unknown origin) expressed in antiCD3-antibody-stimulated human J... 来源：ChEMBL 靶标：Tyrosine-protein phosphatase non-receptor type 1 External Id：CHEMBL3387317

实验名称：Inhibition of STEP (unknown origin) expressed in antiCD3-antibody-stimulated human Ju... 来源：ChEMBL 靶标：Tyrosine-protein phosphatase non-receptor type 5 External Id：CHEMBL3387316

实验名称：Inhibition of Lyp in antiCD3-antibody-stimulated human JTAg cells assessed as increas... 来源：ChEMBL 靶标：Tyrosine-protein phosphatase non-receptor type 22 External Id：CHEMBL3387319

实验名称：Inhibition of Lyp in antiCD3-antibody-stimulated human JTAg cells assessed as increas... 来源：ChEMBL 靶标：Tyrosine-protein phosphatase non-receptor type 22 External Id：CHEMBL3387318

实验名称：Inhibition of Lyp in antiCD3-antibody-stimulated human JTAg cells assessed as increas... 来源：ChEMBL 靶标：Tyrosine-protein phosphatase non-receptor type 22 External Id：CHEMBL3387321

实验名称：Inhibition of Lyp in antiCD3-antibody-stimulated human JTAg cells assessed as increas... 来源：ChEMBL 靶标：Tyrosine-protein phosphatase non-receptor type 22 External Id：CHEMBL3387320

实验名称：Inhibition of N-terminal His-tagged Lyp (unknown origin) catalytic domain (1 to 294 r... 来源：ChEMBL 靶标：Tyrosine-protein phosphatase non-receptor type 22 External Id：CHEMBL3384864

实验名称：Reversible inhibition of N-terminal His-tagged Lyp (unknown origin) catalytic domain ... 来源：ChEMBL 靶标：Tyrosine-protein phosphatase non-receptor type 22 External Id：CHEMBL3384863

实验名称：Inhibition of Lyp in antiCD3-antibody-stimulated human JTAg cells assessed as increas... 来源：ChEMBL 靶标：Tyrosine-protein phosphatase non-receptor type 22 External Id：CHEMBL3386723

实验名称：Selectivity index, ratio of IC50 for PTP1B (unknown origin) to IC50 for N-terminal Hi... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3386722

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