哌啶-4-磺酸

更新时间：2024-01-05 17:05:22

哌啶-4-磺酸结构式	常用名	哌啶-4-磺酸	英文名	4-BROMO-BENZENESULFONIC ACID
	CAS号	72450-62-5	分子量	165.21
	密度	1.39g/cm3	沸点	N/A
	分子式	C₅H₁₁NO₃S	熔点	> 300 °C
	MSDS	中文版美版	闪点	N/A

哌啶-4-磺酸用途

Piperidine-4-sulfonic acid 是一种有效的 GABA 激动剂,抑制 H-GABA 的结合,IC50 为 0.034 μM。

中文名	哌啶-4-磺酸
英文名	piperidine-4-sulfonic acid
英文别名	更多

描述	Piperidine-4-sulfonic acid 是一种有效的 GABA 激动剂,抑制 H-GABA 的结合,IC50 为 0.034 μM。
相关类别	信号通路 >> 其他 >> 其他信号通路 >> 跨膜转运 >> GABA受体研究领域 >> 神经疾病信号通路 >> 神经信号通路 >> GABA受体
靶点	IC50: 0.034 μM (the binding of H-GABA)[1]
参考文献	[1]. POVL KROGSGAARD-LARSEN, et al. Pharmacological Studies of Interactions Between Benzodiazepines and GABA Receptors. Brain Research Rullrrin. 1980, 5(2):867-872. [2]. Krogsgaard-Larsen P, Arnt J. Pharmacological studies of interactions between benzodiazepines and GABA receptors. Brain Research Bulletin, 1980, 5: 867-872.

密度	1.39g/cm3
熔点	> 300 °C
分子式	C₅H₁₁NO₃S
分子量	165.21
精确质量	165.04600
PSA	74.78000
LogP	1.03580
外观性状	白色固体
折射率	1.537
储存条件	室温

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危险品运输编码	NONH for all modes of transport
海关编码	2933399090

海关编码	2933399090
中文概述	2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Modulation of [3H]diazepam binding in rat cortical membranes by GABAA agonists.

J. Neurochem. 44(4) , 1162-7, (1985)

GABAA receptor agonists modulate [3H]diazepam binding in rat cortical membranes with different efficacies. At 23 degrees C, the relative potencies for enhancement of [3H]diazepam binding by agonists p...

Effects of GABA(A) receptor partial agonists in primary cultures of cerebellar granule neurons and cerebral cortical neurons reflect different receptor subunit compositions.

Br. J. Pharmacol. 133(4) , 539-49, (2001)

Based on an unexpected high maximum response to piperidine-4-sulphonic acid (P4S) at human alpha1alpha6beta2gamma2 GABA(A) receptors expressed in Xenopus oocytes attempts to correlate this finding wit...

Inhibition of rabbit brain 4-aminobutyrate transaminase by some taurine analogues: a kinetic analysis.

Biochem. Pharmacol. 71(10) , 1510-9, (2006)

The use of the antiepileptic drug, 4-aminobutyrate transaminase (GABA-T) inhibitor vigabatrin (VIGA), has been recently cautioned because it is associated to irreversible field defects from damage of ...

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