3-(4-吡啶)吲哚

• 常用名: 3-(4-吡啶)吲哚
• 英文名: Rho Kinase Inhibitor III,Rockout
• CAS号: 7272-84-6
• 分子量: 194.23200
• 密度: 1.211g/cm3
• 沸点: 406.7ºC at 760 mmHg
• 分子式: C₁₃H₁₀N₂
• 熔点: N/A
• 闪点: 185.2ºC

3-(4-吡啶)吲哚用途

3-(4-吡啶基)吲哚(Rockout)是一种Rho激酶(ROCK)抑制剂,IC50为25μM。在伤口愈合试验中,3-(4-吡啶基)吲哚可抑制起泡并导致肌动蛋白应力纤维溶解【1】。

3-(4-吡啶)吲哚名称

• 中文名: 3-(4-吡啶)吲哚
• 英文名: 3-pyridin-4-yl-1H-indole

3-(4-吡啶)吲哚生物活性

• 描述: 3-(4-吡啶基)吲哚(Rockout)是一种Rho激酶(ROCK)抑制剂,IC50为25μM。在伤口愈合试验中,3-(4-吡啶基)吲哚可抑制起泡并导致肌动蛋白应力纤维溶解【1】。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> 岩石
  研究领域 >> 炎症/免疫
  信号通路 >> 干细胞及 Wnt 通路 >> 岩石
  信号通路 >> TGF-beta/Smad 信号通路 >> 岩石
• 参考文献:

  [1]. Yarrow JC, et, al. Screening for cell migration inhibitors via automated microscopy reveals a Rho-kinase inhibitor. Chem Biol. 2005 Mar;12(3):385-95.

3-(4-吡啶)吲哚物理化学性质

• 密度: 1.211g/cm3
• 沸点: 406.7ºC at 760 mmHg
• 分子式: C₁₃H₁₀N₂
• 分子量: 194.23200
• 闪点: 185.2ºC
• 精确质量: 194.08400
• PSA: 28.68000
• LogP: 3.22990
• InChIKey: LLJRXVHJOJRCSM-UHFFFAOYSA-N
• SMILES: c1ccc2c(-c3ccncc3)c[nH]c2c1
• 折射率: 1.688
• 储存条件: -20°C

3-(4-吡啶)吲哚靶点实验

查看更多实验

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：qHTS for Inhibitors of TGF-b: Cytotox Counterscreen 来源：NCGC 靶标：N/A External Id：SMAD3201

实验名称：uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay 来源：Burnham Center for Chemical Genomics 靶标：cystic fibrosis transmembrane conductance regulator [Homo sapiens] External Id：SBCCG-A764-CF-PAF-Primary-Assay

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ant... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_ANT_FLUO8_1536_1X%INH PRUN

实验名称：qHTS for Inhibitors of TGF-b 来源：NCGC 靶标：Smad3 [Homo sapiens] External Id：SMAD3101

实验名称：Fluorescence-based biochemical high throughput primary assay to identify inhibitors o... 来源：The Scripps Research Institute Molecular Screening Center 靶标：Trypanosoma brucei RNA editing ligase 1 External Id：TBREL1_INH_FRET_1536_1X%INH PRUN

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify act... 来源：The Scripps Research Institute Molecular Screening Center 靶标：TTR [Homo sapiens] External Id：TTR_ACT_LUMI_1536_1X%ACT PRUN

实验名称：Millipore: Percentage of residual kinase activity of PRKAA2 at 10uM relative to contr... 来源：ChEMBL 靶标：5'-AMP-activated protein kinase catalytic subunit alpha-1 External Id：CHEMBL2219380

实验名称：Millipore: Percentage of residual kinase activity of NUAK1 at 1uM relative to control... 来源：ChEMBL 靶标：NUAK family SNF1-like kinase 1 External Id：CHEMBL2219381

共596条，当前第1页，共60页

1

2

3

4

5

3-(4-吡啶)吲哚英文别名

• rockout
• 3-(4-Pyridyl)-1H-indole
• 3-<Pyridyl-(4)>-indol
• 3-(pyridin-4-yl)-1H-indole
• 3-(PYRIDIN-4-YL)INDOLE
• 3-(4-Pyridyl)indole
• 4-(3-indolyl)-pyridine