米仔兰碱

• 常用名: 米仔兰碱
• 英文名: Odorine
• CAS号: 72755-20-5
• 分子量: 300.40
• 密度: 1.1±0.1 g/cm3
• 沸点: 551.3±40.0 °C at 760 mmHg
• 分子式: C₁₈H₂₄N₂O₂
• 熔点: N/A
• 闪点: 287.2±27.3 °C

米仔兰碱用途

气味素(Roxburghiline)是一种天然产物,是从臭藤(Aglaia odorata)的枝和叶中分离得到的。奥多林具有潜在的抗肿瘤活性,可以抑制皮肤癌症的发生和发展阶段[1]。

米仔兰碱名称

• 中文名: 米仔兰碱
• 英文名: odorine

米仔兰碱生物活性

• 描述: 气味素(Roxburghiline)是一种天然产物,是从臭藤(Aglaia odorata)的枝和叶中分离得到的。奥多林具有潜在的抗肿瘤活性,可以抑制皮肤癌症的发生和发展阶段[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. A Inad, et al. Cancer chemopreventive activity of odorine and odorinol from Aglaia odorata. Biol Pharm Bull. 2001 Nov;24(11):1282-5.

米仔兰碱物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 551.3±40.0 °C at 760 mmHg
• 分子式: C₁₈H₂₄N₂O₂
• 分子量: 300.40
• 闪点: 287.2±27.3 °C
• 精确质量: 300.183777
• PSA: 49.41000
• LogP: 1.89
• InChIKey: KZAOEMMZRGEBST-UHFFFAOYSA-N
• SMILES: CCC(C)C(=O)NC1CCCN1C(=O)C=Cc1ccccc1
• 外观性状: 粉末
• 蒸汽压: 0.0±1.5 mmHg at 25°C
• 折射率: 1.563
• 储存条件: 2-8℃，干燥，密闭

米仔兰碱安全信息

• 危害码 (欧洲): Xi

米仔兰碱靶点实验

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实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

实验名称：Absorbance-based primary biochemical high throughput screening assay to identify acti... 来源：The Scripps Research Institute Molecular Screening Center 靶标：caspase-3 preproprotein [Homo sapiens] External Id：PROCASPASE3_ACT_EPIABS_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule modulators of NR3A 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：SBCCG-A1015-NR3A-Primary-Assay

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米仔兰碱英文别名

• Roxburghilin
• (2R)-2-Methyl-N-{(2R)-1-[(2E)-3-phenyl-2-propenoyl]-2-pyrrolidinyl}butanamide
• Roxburghiline
• 2-Epiroxburghilin
• (2R)-2-Methyl-N-{1-[(2E)-3-phenyl-2-propenoyl]-2-pyrrolidinyl}butanamide