α,β-亚甲基腺苷5'-三磷酸三钠盐

• 常用名: α,β-亚甲基腺苷5'-三磷酸三钠盐
• 英文名: α,β-Methylene-ATP
• CAS号: 7292-42-4
• 分子量: 505.20800
• 密度: 2.5g/cm3
• 沸点: 968.2ºC at 760 mmHg
• 分子式: C₁₁H₁₈N₅O₁₂P₃
• 熔点: N/A
• 闪点: 539.3ºC

用途

α、 β-亚甲基ATP是ATP的膦酸类似物,是P2X3和P2X7受体配体。α、 β-亚甲基ATP是P2X1和P2X3的高选择性激动剂,在P2X2,4-7[1][2]几乎没有活性。

名称

• 中文名: α,β-亚甲基腺苷5'-三磷酸三钠盐
• 英文名: [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-[[hydroxy(phosphonooxy)phosphoryl]methyl]phosphinic acid

生物活性

• 描述: α、 β-亚甲基ATP是ATP的膦酸类似物,是P2X3和P2X7受体配体。α、 β-亚甲基ATP是P2X1和P2X3的高选择性激动剂,在P2X2,4-7[1][2]几乎没有活性。
• 相关类别:
  研究领域 >> 炎症/免疫
  信号通路 >> 跨膜转运 >> P2X受体
• 参考文献:

  [1]. Arribas-Blázquez M, et al. Overexpression of P2X3 and P2X7 Receptors and TRPV1 Channels in Adrenomedullary Chromaffin Cells in a Rat Model of Neuropathic Pain. Int J Mol Sci. 2019 Jan 3;20(1).

  [2]. Claudio Coddou, et al. Activation and regulation of purinergic P2X receptor channels. Pharmacol Rev. 2011 Sep;63(3):641-83

物理化学性质

• 密度: 2.5g/cm3
• 沸点: 968.2ºC at 760 mmHg
• 分子式: C₁₁H₁₈N₅O₁₂P₃
• 分子量: 505.20800
• 闪点: 539.3ºC
• 精确质量: 505.01600
• PSA: 299.33000
• InChIKey: CAWZRIXWFRFUQB-IOSLPCCCSA-N
• SMILES: Nc1ncnc2c1ncn2C1OC(COP(=O)(O)CP(=O)(O)OP(=O)(O)O)C(O)C1O
• 折射率: 1.887

靶点实验

查看更多实验

实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-p1-antagonist

实验名称：Antagonist activity against recombinant rat receptor P2X purinoceptor 2 (P2X2) at 10 ... 来源：ChEMBL 靶标：P2X purinoceptor 2 External Id：CHEMBL751111

实验名称：Relative inhibitory potency T/II in rat methionine adenosyltransferase 来源：ChEMBL 靶标：S-adenosylmethionine synthase isoform type-1 External Id：CHEMBL845626

实验名称：Evaluated for agonist activity against phospholipase C coupled P2Y purinoceptor 1 (P2... 来源：ChEMBL 靶标：P2Y purinoceptor 1 External Id：CHEMBL759187

实验名称：Experimentally measured binding affinity data (Ki) for protein-ligand complexes deriv... 来源：Shanghai Institute of Organic Chemistry 靶标：N/A External Id：PDBbind-Ki for protein-ligand complexes

实验名称：Antagonist activity against recombinant human P2X purinoceptor 3 (P2X3 ) 来源：ChEMBL 靶标：P2X purinoceptor 3 External Id：CHEMBL751806

实验名称：Inhibitory potency against rat Methionine adenosyltransferase was reported 来源：ChEMBL 靶标：S-adenosylmethionine synthase isoform type-1 External Id：CHEMBL709692

实验名称：Experimentally measured binding affinity data (Kd) for protein-ligand complexes deriv... 来源：Shanghai Institute of Organic Chemistry 靶标：N/A External Id：PDBbind-Kd for protein-ligand complexes

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1100

实验名称：qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primar... 来源：NCGC 靶标：67.9K protein [Vaccinia virus] External Id：Vaccinia-p2mCherry

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英文别名

• Adenosine 5'-[[hydroxy(phosphonooxy)phosphinyl]methyl] phosphonate
• Einecs 230-723-9
• α,β-Methyleneadenosine 5'-triphosphate trisodium salt
• adenosine 5'-[hydrogen [[hydroxy(phosphonooxy)phosphinyl]methyl]phosphonate]
• Adenosine-5'-methylenediphosphono-P2-phosphate
• 5'-(Hydrogen((hydroxy(phosphonooxy)phosphinyl)methyl)phosphonate)adenosine
• α,β-Methyleneadenosine5'-triphosphatetrisodiumsalt
• Adenosine 5'-[[[hydroxy(phosphonooxy)phosphinyl]methyl] phosphonate]
• (α,β-Methylene)adenosine triphosphate