Itanapraced

• 常用名: Itanapraced
• 英文名: CHF5074
• CAS号: 749269-83-8
• 分子量: 325.16200
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₆H₁₁Cl₂FO₂
• 熔点: N/A
• 闪点: N/A

Itanapraced用途

Itanapraced (CHF5074) 是一种新型γ-secretase调节剂, 降低 Aβ42 和Aβ40 分泌, IC50分别为3.6和18.4 μM。

Itanapraced名称

• 中文名: Itanapraced
• 英文名: 1-[4-(3,4-dichlorophenyl)-3-fluorophenyl]cyclopropane-1-carboxylic acid

Itanapraced生物活性

• 描述: Itanapraced (CHF5074) 是一种新型γ-secretase调节剂, 降低 Aβ42 和Aβ40 分泌, IC50分别为3.6和18.4 μM。
• 相关类别:
  信号通路 >> 神经信号通路 >> γ分泌酶
  信号通路 >> 干细胞及 Wnt 通路 >> γ分泌酶
  研究领域 >> 神经疾病
• 靶点实验:

  IC50 value: 3.6 μM (Aβ42), 18.4 μM (Aβ40) [1]

• 参考文献:

  [1]. Imbimbo BP, et al. 1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretasemodulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease withoutcausing peripheral toxicity. J Pharmacol Exp Ther. 2007 Dec;323(3):822-830.

  [2]. Mango D, et al. Electrophysiological and metabolic effects of CHF5074 in the hippocampus: protection against in vitro ischemia. Pharmacol Res. 2014 Mar;81:83-90.

Itanapraced物理化学性质

• 分子式: C₁₆H₁₁Cl₂FO₂
• 分子量: 325.16200
• 精确质量: 324.01200
• PSA: 37.30000
• LogP: 4.91570
• InChIKey: LIYLTQQDABRNRX-UHFFFAOYSA-N
• SMILES: O=C(O)C1(c2ccc(-c3ccc(Cl)c(Cl)c3)c(F)c2)CC1
• 外观性状: 粉末
• 储存条件: -20℃

Itanapraced靶点实验

查看更多实验

实验名称：Antialzheimer activity in transgenic hAPP mouse expressing Swedish and London mutatio... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL2155450

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Brain penetration in mouse assessed as brain/plasma ratio at 100 or 300 mg/kg/day for... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL2155447

实验名称：Absolute oral bioavailability after administration to rats at a dose of 0.5 mg/kg ora... 来源：ChEMBL 靶标：N/A External Id：CHEMBL880318

实验名称：Antialzheimer activity in transgenic hAPP mouse expressing Swedish and London mutatio... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL2155453

实验名称：Antialzheimer activity in transgenic Alzheimer disease mouse model assessed as increa... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL2155454

实验名称：Antialzheimer activity in transgenic hAPP mouse expressing Swedish and London mutatio... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL2155451

实验名称：Antialzheimer activity in transgenic hAPP mouse expressing Swedish and London mutatio... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL2155452

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

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Itanapraced英文别名

• unii-c35rf1mwqz
• h50
• chf-5074
• CHF5074