2-(6-amino-8-prop-2-enylsulfanyl-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

• 常用名: 2-(6-amino-8-prop-2-enylsulfanyl-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
• 英文名: 2-(6-amino-8-prop-2-enylsulfanyl-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
• CAS号: 75059-23-3
• 分子量: 339.37
• 密度: 1.78g/cm3
• 沸点: 681.5ºC at 760mmHg
• 分子式: C₁₃H₁₇N₅O₄S
• 熔点: N/A
• 闪点: N/A

用途

8-烯丙基硫腺苷是一种腺苷类似物。腺苷类似物主要起到平滑肌血管扩张剂的作用,也被证明可以抑制癌症的进展。其受欢迎的产品有磷酸腺苷、阿卡地辛(HY-13417)、氯法拉滨(HY-A0005)、磷酸氟达拉滨(HY-B0028)和维达拉宾(HY-B0277)[1]。

名称

• 英文名: 2-(6-amino-8-prop-2-enylsulfanylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

生物活性

• 描述: 8-烯丙基硫腺苷是一种腺苷类似物。腺苷类似物主要起到平滑肌血管扩张剂的作用,也被证明可以抑制癌症的进展。其受欢迎的产品有磷酸腺苷、阿卡地辛(HY-13417)、氯法拉滨(HY-A0005)、磷酸氟达拉滨(HY-B0028)和维达拉宾(HY-B0277)[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
• 参考文献:

  [1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

  [2]. Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26(6):1490-1500.

物理化学性质

• 密度: 1.78g/cm3
• 沸点: 681.5ºC at 760mmHg
• 分子式: C₁₃H₁₇N₅O₄S
• 分子量: 339.37
• 精确质量: 339.10000
• PSA: 164.84000
• InChIKey: ZATIFJKJPWWYAJ-UHFFFAOYSA-N
• SMILES: C=CCSc1nc2c(N)ncnc2n1C1OC(CO)C(O)C1O
• 折射率: 1.802

靶点实验

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