PRE-084

• 常用名: PRE-084
• 英文名: PRE-084 (hydrochloride)
• CAS号: 75136-54-8
• 分子量: 353.884
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₂₈ClNO₃
• 熔点: N/A
• 闪点: N/A

PRE-084用途

PRE-084盐酸盐是一种高亲合性的选择性σ1激动剂, 在sigma受体检测中IC50值为44 nM。

PRE-084名称

• 中文名: PRE-084盐酸盐
• 英文名: PRE-084 (hydrochloride)

PRE-084生物活性

• 描述: PRE-084盐酸盐是一种高亲合性的选择性σ1激动剂, 在sigma受体检测中IC50值为44 nM。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> Sigma Receptor
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Su TP, et al. Sigma compounds derived from phencyclidine: identification of PRE-084, a new, selective sigma ligand. J Pharmacol Exp Ther. 1991 Nov;259(2):543-550.

  [2]. Peviani M, et al. Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation. Neurobiol Dis. 2014 Feb;62:218-232.

PRE-084物理化学性质

• 分子式: C₁₉H₂₈ClNO₃
• 分子量: 353.884
• 精确质量: 353.175781
• PSA: 38.77000
• LogP: 3.50380
• InChIKey: QUJWFJNHTBKCLU-UHFFFAOYSA-N
• SMILES: Cl.O=C(OCCN1CCOCC1)C1(c2ccccc2)CCCCC1
• 外观性状: 白色至类白色固体
• 储存条件: -20℃

PRE-084靶点实验

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实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：Tocris HTS for Inhibitors of Aerobactin Synthetase lucA 来源：23265 External Id：IucA Pilot Assay Tocris Library

实验名称：Dicer-mediated maturation of pre-microRNA 来源：Center for Chemical Genomics, University of Michigan 靶标：N/A External Id：TargetID_659_CEMA

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

实验名称：Absorbance-based primary biochemical high throughput screening assay to identify acti... 来源：The Scripps Research Institute Molecular Screening Center 靶标：caspase-3 preproprotein [Homo sapiens] External Id：PROCASPASE3_ACT_EPIABS_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule modulators of NR3A 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：SBCCG-A1015-NR3A-Primary-Assay

实验名称：uHTS identification of small molecule modulators of Rev-erb Alpha. 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：SBCCG-A1016-RevErbaLBD-Primary-Assay

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PRE-084英文别名

• PRE 084 hydrochloride
• 2-morpholinoacetohydrazide
• N-amino-2-morpholin-4-ylacetamide
• N-morpholinylacetic acid hydrazide
• 2-(4-Morpholinyl)ethyl 1-phenylcyclohexanecarboxylate hydrochloride (1:1)
• morpholin-4-yl-acetic acid hydrazide
• 2-(Morpholin-4-yl)ethyl 1-phenylcyclohexanecarboxylate hydrochloride (1:1)
• Cyclohexanecarboxylic acid, 1-phenyl-, 2-(4-morpholinyl)ethyl ester, hydrochloride (1:1)