N-[(7R)-1,2,3,10-四甲氧基-9-氧代-6,7-二氢-5H-苯并[d]庚搭烯-7-基]乙酰胺

• 常用名: N-[(7R)-1,2,3,10-四甲氧基-9-氧代-6,7-二氢-5H-苯并[d]庚搭烯-7-基]乙酰胺
• 英文名: (+)-Colchicin
• CAS号: 75520-89-7
• 分子量: 399.43700
• 密度: 1.25g/cm3
• 沸点: 726ºC at 760 mmHg
• 分子式: C₂₂H₂₅NO₆
• 熔点: 106-132ºC
• 闪点: 392.9ºC

名称

• 中文名: N-[(7R)-1,2,3,10-四甲氧基-9-氧代-6,7-二氢-5H-苯并[d]庚搭烯-7-基]乙酰胺
• 英文名: N-[(7R)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide

物理化学性质

• 密度: 1.25g/cm3
• 沸点: 726ºC at 760 mmHg
• 熔点: 106-132ºC
• 分子式: C₂₂H₂₅NO₆
• 分子量: 399.43700
• 闪点: 392.9ºC
• 精确质量: 399.16800
• PSA: 83.09000
• LogP: 3.26250
• InChIKey: IAKHMKGGTNLKSZ-MRXNPFEDSA-N
• SMILES: COc1cc2c(c(OC)c1OC)-c1ccc(OC)c(=O)cc1C(NC(C)=O)CC2
• 折射率: 1.584

毒性和生态

靶点实验

查看更多实验

实验名称：Validation qHTS for agonist of cAMP-regulated guanine nucleotide exchange factor 3 (E... 来源：NCGC External Id：epac1-activator-v

实验名称：Toxicity found after a single im injection. The total number of deaths were counted a... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL727958

实验名称：qHTS for inhibitors of Vif-A3G interactions: Validation 来源：NCGC 靶标：DNA dC->dU-editing enzyme APOBEC-3G [Homo sapiens] External Id：VIFG001

实验名称：Validation qHTS for antagonist of cAMP-regulated guanine nucleotide exchange factor 3... 来源：NCGC External Id：epac1-inhibitor-v

实验名称：Inhibition of [3H]colchicine binding to microtubule protein tubulin 来源：ChEMBL 靶标：Tubulin alpha-3C chain External Id：CHEMBL820637

实验名称：Validation qHTS for agonist of cAMP-regulated guanine nucleotide exchange factor 4 (E... 来源：NCGC External Id：epac2-activator-v2

实验名称：Validation qHTS for antagonist of cAMP-regulated guanine nucleotide exchange factor 4... 来源：NCGC External Id：epac2-inhibitor-v2

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1100

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1101

实验名称：qHTS for Inhibitors of Polymerase Kappa 来源：NCGC 靶标：DNA polymerase kappa [Homo sapiens] External Id：PolK100

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英文别名

• (+)-Colchicin
• COLCHICINE,(+)
• Acetamide,N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-,(R)
• (R)-7-Acetylamino-1,2,3,10-tetramethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-on
• Lopac-C-9754
• Colchicine,(R)-Isomer