三甲基秋水仙酸

• 常用名: 三甲基秋水仙酸
• 英文名: Trimethylcolchicinic acid
• CAS号: 3482-37-9
• 分子量: 343.37400
• 密度: 1.32g/cm3
• 沸点: 629ºC at 760mmHg
• 分子式: C₁₉H₂₁NO₅
• 熔点: >230ºC (dec.)
• 闪点: 334.2ºC
• 符号: GHS07
• 信号词: Warning

三甲基秋水仙酸用途

Trimethylcolchicinic acid is an antimitotic agent disrupting microtubule action through the binding of tubulin and preventing polymerization. Has been shown to stimulate the intrinsic GTPase activity of tubulin. Induces apoptosis and activates the JNK/SAPK signals.

三甲基秋水仙酸名称

• 中文名: 三甲基秋水仙素酸
• 英文名: N-Deacetyl Colchiceine

三甲基秋水仙酸物理化学性质

• 密度: 1.32g/cm3
• 沸点: 629ºC at 760mmHg
• 熔点: >230ºC (dec.)
• 分子式: C₁₉H₂₁NO₅
• 分子量: 343.37400
• 闪点: 334.2ºC
• 精确质量: 343.14200
• PSA: 91.01000
• LogP: 3.09150
• InChIKey: IRVWPZRYDQROLU-ZDUSSCGKSA-N
• SMILES: COc1cc2c(c(OC)c1OC)-c1ccc(O)c(=O)cc1C(N)CC2
• 折射率: 1.628
• 储存条件: −20°C

三甲基秋水仙酸毒性和生态

三甲基秋水仙酸安全信息

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302-H312-H332
• 警示性声明: P280
• 危害码 (欧洲): Xn: Harmful;
• 风险声明 (欧洲): 20/21/22
• 安全声明 (欧洲): 36
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3
• RTECS号: GH0960000

三甲基秋水仙酸靶点实验

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实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Cytotoxicity against human H9 cells 来源：ChEMBL 靶标：H9 External Id：CHEMBL1019291

实验名称：Antiviral activity against HIV1 HTLV-3B in human H9 cells after 3 days by p24 antigen... 来源：ChEMBL 靶标：Human immunodeficiency virus 1 External Id：CHEMBL1019290

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

实验名称：Absorbance-based primary biochemical high throughput screening assay to identify acti... 来源：The Scripps Research Institute Molecular Screening Center 靶标：caspase-3 preproprotein [Homo sapiens] External Id：PROCASPASE3_ACT_EPIABS_1536_1X%ACT PRUN

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三甲基秋水仙酸英文别名

• trimethylcolchicinic acid