盐酸莫索尼定

• 常用名: 盐酸莫索尼定
• 英文名: Moxonidine hydrochloride
• CAS号: 75536-04-8
• 分子量: 278.138
• 密度: N/A
• 沸点: N/A
• 分子式: C₉H₁₃Cl₂N₅O
• 熔点: N/A
• 闪点: N/A

盐酸莫索尼定用途

Moxonidine(BDF5895)盐酸盐是咪唑啉1型受体（I1-R）选择性激动剂，为降压剂。

盐酸莫索尼定名称

• 中文名: 盐酸莫索尼定
• 英文名: Moxonidine hydrochloride

盐酸莫索尼定生物活性

• 描述: Moxonidine(BDF5895)盐酸盐是咪唑啉1型受体(I1-R)选择性激动剂,为降压剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 咪唑啉受体
  信号通路 >> 神经信号通路 >> 咪唑啉受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Schafer, U., et al., Presynaptic effects of moxonidine in isolated buffer perfused rat hearts: role of imidazoline-1 receptors and alpha2-adrenoceptors. J Pharmacol Exp Ther, 2002. 303(3): p. 1163-70.

  [2]. Chan, C.K., et al., Imidazoline receptors associated with noradrenergic terminals in the rostral ventrolateral medulla mediate the hypotensive responses of moxonidine but not clonidine. Neuroscience, 2005. 132(4): p. 991-1007.

盐酸莫索尼定物理化学性质

• 分子式: C₉H₁₃Cl₂N₅O
• 分子量: 278.138
• 精确质量: 277.049713
• InChIKey: ZZPAWQYZQVUVHX-UHFFFAOYSA-N
• SMILES: COc1nc(C)nc(Cl)c1NC1=NCCN1.Cl
• 储存条件: 2-8℃

盐酸莫索尼定靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：qHTS to identify inhibitors of the New Delhi Metallo-beta-lactamase (NDM): assay vali... 来源：NCGC External Id：adst_MBL_Abs_LOPAC_o1

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL1266185

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020);... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL4296184

实验名称：Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); ... 来源：ChEMBL 靶标：Klebsiella pneumoniae External Id：CHEMBL4296186

实验名称：Antibacterial activity against Escherichia coli ATCC 25922 (CO-ADD:GN_001); MIC in CA... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL4296185

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盐酸莫索尼定英文别名

• 5-Pyrimidinamine, 4-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methyl-, hydrochloride (1:1)
• 4-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methylpyrimidin-5-amine hydrochloride (1:1)
• 5RYW07SK5E
• Moxonidine hydrochloride
• Moxonidine HCl
• 4-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methyl-5-pyrimidinamine hydrochloride (1:1)
• MFCD06795643