Debromohymenialdisine

• 常用名: Debromohymenialdisine
• 英文名: Debromohymenialdisine
• CAS号: 75593-17-8
• 分子量: 245.237
• 密度: 1.8±0.1 g/cm3
• 沸点: N/A
• 分子式: C₁₁H₁₁N₅O₂
• 熔点: >250ºC (dec.)
• 闪点: N/A

Debromohymenialdisine用途

德布罗梅尼亚尔丁(10Z德布罗梅尼亚尔丁)是一种吡咯生物碱。在最初的Raf/MEK-1/MAPK信号级联测定中,德布罗美尼阿尔定具有中等的抑制活性,IC50值为881nM。德布罗莫美尼尔可用于研究增殖和分化[1]。

Debromohymenialdisine名称

• 英文名: (4Z)-4-(2-amino-4-oxo-1H-imidazol-5-ylidene)-1,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8-one

Debromohymenialdisine生物活性

• 描述: 德布罗梅尼亚尔丁(10Z德布罗梅尼亚尔丁)是一种吡咯生物碱。在最初的Raf/MEK-1/MAPK信号级联测定中,德布罗美尼阿尔定具有中等的抑制活性,IC50值为881nM。德布罗莫美尼尔可用于研究增殖和分化[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> MAPK/ERK信号通路 >> MEK
  信号通路 >> MAPK/ERK信号通路 >> 拉夫
• 靶点实验:

  IC50: 881 nM (in Raf/MEK-1/MAPK signaling cascade assay)[1].

• 体外研究: 在初始Raf/MEK-1/MAPK信号级联测定中,德布罗美尼阿尔定具有中等的抑制活性,IC50值为881nM[1]。
• 参考文献:

  [1]. Deniz Tasdemir, et al. Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1). J Med Chem. 2002 Jan 17;45(2):529-32.

Debromohymenialdisine物理化学性质

• 密度: 1.8±0.1 g/cm3
• 熔点: >250ºC (dec.)
• 分子式: C₁₁H₁₁N₅O₂
• 分子量: 245.237
• 精确质量: 245.091278
• PSA: 116.85000
• LogP: -0.14
• 折射率: 1.878

Debromohymenialdisine靶点实验

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实验名称：Inhibition of USP7 (unknown origin) using ubiquitin-EKL as substrate at 20 uM 来源：ChEMBL 靶标：Ubiquitin carboxyl-terminal hydrolase 7 External Id：CHEMBL2400587

实验名称：Selectivity ratio of IC50 for Chk1 (unknown origin) to IC50 for (unknown origin) 来源：ChEMBL 靶标：N/A External Id：CHEMBL5227460

实验名称：Kinase assays for IC50 determinations from Article 10.1016/j.bmc.2005.10.022: "Identi... 来源：BindingDB 靶标：N/A External Id：BindingDB_2065_2

实验名称：Antiarthritic activity in adjuvant-induced arthritis rat model assessed as reduction ... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL5227457

实验名称：Antiarthritic activity in adjuvant-induced arthritis rat model assessed as reduction ... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL5227456

实验名称：Cytotoxicity against mouse P388 cells assessed as concentration required for 50% inhi... 来源：ChEMBL 靶标：P388 External Id：CHEMBL925899

实验名称：Inhibition of human Chk2 using STK1 as substrate after 10 mins by HTRF assay 来源：ChEMBL 靶标：Serine/threonine-protein kinase Chk2 External Id：CHEMBL1947437

实验名称：Inhibition of human CHK1 using STK1 as substrate after 10 mins by HTRF assay 来源：ChEMBL 靶标：Serine/threonine-protein kinase Chk1 External Id：CHEMBL1947436

实验名称：Selectivity ratio of IC50 for human CHK1 to IC50 for human CHK2 来源：ChEMBL 靶标：N/A External Id：CHEMBL1947438

实验名称：Cytotoxicity against mouse L5178Y cells by MTT assay 来源：ChEMBL 靶标：L5178Y External Id：CHEMBL5227443

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Debromohymenialdisine英文别名

• 2c3j
• (Z)-2-Debromohymenialdisine
• (4Z)-4-(2-Amino-5-oxo-1,5-dihydro-4H-imidazol-4-ylidene)-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8(1H)-one
• Debromohymenialdisine
• (Z)-Debromohymenialdisine
• debromohymenialdesine