11-羟基-6-铁屎米酮

• 常用名: 11-羟基-6-铁屎米酮
• 英文名: 11-Hydroxycanthin-6-one
• CAS号: 75969-83-4
• 分子量: 236.22600
• 密度: 1.55g/cm3
• 沸点: 569.7ºC at 760mmHg
• 分子式: C₁₄H₈N₂O₂
• 熔点: 327-329 ºC
• 闪点: 298.3ºC

11-羟基-6-铁屎米酮用途

11-羟基角蛋白-6-酮是一种角蛋白-6-酮生物碱,是一种抗肿瘤剂,显示出强大的细胞毒活性[1][2]。

11-羟基-6-铁屎米酮名称

• 中文名: 11-羟基-6-铁屎米酮
• 英文名: 11-hydroxy-canthin-6-one
• 中文别名: 11-羟基-6H-吲哚并[3,2,1-de][1,5]萘啶-6-酮

11-羟基-6-铁屎米酮生物活性

• 描述: 11-羟基角蛋白-6-酮是一种角蛋白-6-酮生物碱,是一种抗肿瘤剂,显示出强大的细胞毒活性[1][2]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Fukamiya N, et, al. Antitumor agents: LXXXVII. Cytotoxic antileukemic canthin-6-one alkaloids from Brucea antidysenterica and the structure activity relationships of their related derivatives. Planta Med. 1987 Apr;53(2):140-3.

  [2]. Miyake K, et, al. Canthin-6-one alkaloids and a tirucallanoid from Eurycoma longifolia and their cytotoxic activity against a human HT-1080 fibrosarcoma cell line. Nat Prod Commun. 2010 Jan;5(1):17-22.

11-羟基-6-铁屎米酮物理化学性质

• 密度: 1.55g/cm3
• 沸点: 569.7ºC at 760mmHg
• 熔点: 327-329 ºC
• 分子式: C₁₄H₈N₂O₂
• 分子量: 236.22600
• 闪点: 298.3ºC
• 精确质量: 236.05900
• PSA: 54.60000
• LogP: 2.14430
• InChIKey: IZNXKZBIIFOWPU-UHFFFAOYSA-N
• SMILES: O=c1cccc2c1c1cc[nH]c3ccc(=O)n2c31
• 水溶解性: Very slightly soluble (0.61 g/L) (25 ºC)

11-羟基-6-铁屎米酮靶点实验

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实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：Counterscreen for inhibitors of the Steroid Receptor Coactivator 1 (SRC1; NCOA1): Lum... 来源：The Scripps Research Institute Molecular Screening Center 靶标：transactivating tegument protein VP16 [Human herpesvirus 1] External Id：VP16_INH_LUMI_1536_3X%INH CSRUN for SRC1

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Luminescence-based cell-based high throughput confirmation assay for inhibitors of th... 来源：The Scripps Research Institute Molecular Screening Center 靶标：nuclear receptor coactivator 1 isoform 1 [Homo sapiens] External Id：SRC1_INH_LUMI_1536_3X%INH CRUN

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11-羟基-6-铁屎米酮英文别名

• CANTHIN-6-ONE,11-HYDROXY
• Amalorin
• HMS2268C24
• 11-Hydroxycanthin-6-one
• 11-Hydroxy-6H-indolo[3,2,1-de][1,5]naphthyridin-6-one