11-羟基-6-铁屎米酮

更新时间：2026-06-29 18:21:13

11-羟基-6-铁屎米酮结构式	常用名	11-羟基-6-铁屎米酮	英文名	11-Hydroxycanthin-6-one
	CAS号	75969-83-4	分子量	236.22600
	密度	1.55g/cm3	沸点	569.7ºC at 760mmHg
	分子式	C₁₄H₈N₂O₂	熔点	327-329 ºC
	MSDS	N/A	闪点	298.3ºC

11-羟基-6-铁屎米酮用途

11-羟基角蛋白-6-酮是一种角蛋白-6-酮生物碱,是一种抗肿瘤剂,显示出强大的细胞毒活性[1][2]。

本表展示该化学物质的中文名称、英文系统名、各类中文与英文别名信息。

中文名	11-羟基-6-铁屎米酮
英文名	11-hydroxy-canthin-6-one
中文别名	11-羟基-6H-吲哚并[3,2,1-de][1,5]萘啶-6-酮
英文别名	更多

本表记录该化合物相关生物活性、作用靶点、活性说明与生物实验相关数据。

描述	11-羟基角蛋白-6-酮是一种角蛋白-6-酮生物碱,是一种抗肿瘤剂,显示出强大的细胞毒活性[1][2]。
相关类别	研究领域 >> 癌症信号通路 >> 其他 >> 其他
参考文献	[1]. Fukamiya N, et, al. Antitumor agents: LXXXVII. Cytotoxic antileukemic canthin-6-one alkaloids from Brucea antidysenterica and the structure activity relationships of their related derivatives. Planta Med. 1987 Apr;53(2):140-3. [2]. Miyake K, et, al. Canthin-6-one alkaloids and a tirucallanoid from Eurycoma longifolia and their cytotoxic activity against a human HT-1080 fibrosarcoma cell line. Nat Prod Commun. 2010 Jan;5(1):17-22.

描述

11-羟基角蛋白-6-酮是一种角蛋白-6-酮生物碱,是一种抗肿瘤剂,显示出强大的细胞毒活性[1][2]。

相关类别

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

参考文献

[1]. Fukamiya N, et, al. Antitumor agents: LXXXVII. Cytotoxic antileukemic canthin-6-one alkaloids from Brucea antidysenterica and the structure activity relationships of their related derivatives. Planta Med. 1987 Apr;53(2):140-3.

[2]. Miyake K, et, al. Canthin-6-one alkaloids and a tirucallanoid from Eurycoma longifolia and their cytotoxic activity against a human HT-1080 fibrosarcoma cell line. Nat Prod Commun. 2010 Jan;5(1):17-22.

本表包含该物质理化参数，如熔点、沸点、密度、溶解度、旋光性等理化指标，无数据项标记为N/A。

密度	1.55g/cm3
沸点	569.7ºC at 760mmHg
熔点	327-329 ºC
分子式	C₁₄H₈N₂O₂
分子量	236.22600
闪点	298.3ºC
精确质量	236.05900
PSA	54.60000
LogP	2.14430
InChIKey	IZNXKZBIIFOWPU-UHFFFAOYSA-N
SMILES	O=c1cccc2c1c1cc[nH]c3ccc(=O)n2c31
水溶解性	Very slightly soluble (0.61 g/L) (25 ºC)

本表记录该化合物靶点、体外体内实验、生物测定实验相关实验数据。

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th...
来源：Johns Hopkins Ion Channel Center
靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens]
External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago...
来源：The Scripps Research Institute Molecular Screening Center
靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i...
来源：The Scripps Research Institute Molecular Screening Center
靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago...
来源：The Scripps Research Institute Molecular Screening Center
靶标：muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ...
来源：Burnham Center for Chemical Genomics
靶标：N/A
External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2...
来源：Broad Institute
靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE)
External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect...
来源：Broad Institute
靶标：N/A
External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：Counterscreen for inhibitors of the Steroid Receptor Coactivator 1 (SRC1; NCOA1): Lum...
来源：The Scripps Research Institute Molecular Screening Center
靶标：transactivating tegument protein VP16 [Human herpesvirus 1]
External Id：VP16_INH_LUMI_1536_3X%INH CSRUN for SRC1

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos...
来源：The Scripps Research Institute Molecular Screening Center
靶标：muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Luminescence-based cell-based high throughput confirmation assay for inhibitors of th...
来源：The Scripps Research Institute Molecular Screening Center
靶标：nuclear receptor coactivator 1 isoform 1 [Homo sapiens]
External Id：SRC1_INH_LUMI_1536_3X%INH CRUN

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本表罗列该化合物全部英文别名、系统命名、CAS别名等英文名称集合。

CANTHIN-6-ONE,11-HYDROXY

Amalorin

HMS2268C24

11-Hydroxycanthin-6-one

11-Hydroxy-6H-indolo[3,2,1-de][1,5]naphthyridin-6-one

本部分为该化合物相关常见问答，包含基础参数、性状、储存条件等高频咨询问题与对应答案。

Q: 11-羟基-6-铁屎米酮的SMILES表达式是什么？

A: 11-羟基-6-铁屎米酮SMILES表达式为O=c1cccc2c1c1cc[nH]c3ccc(=O)n2c31。

Q: 11-羟基-6-铁屎米酮的熔点是多少？

A: 11-羟基-6-铁屎米酮熔点为327-329 ºC。