11-Hydroxycanthin-6-one

Modify Date: 2026-06-29 18:21:13

11-Hydroxycanthin-6-one Structure
11-Hydroxycanthin-6-one structure
Common Name 11-Hydroxycanthin-6-one
CAS Number 75969-83-4 Molecular Weight 236.22600
Density 1.55g/cm3 Boiling Point 569.7ºC at 760mmHg
Molecular Formula C14H8N2O2 Melting Point 327-329 ºC
MSDS N/A Flash Point 298.3ºC

 Use of 11-Hydroxycanthin-6-one


11-Hydroxycanthin-6-one, a canthin-6-one alkaloid, is an antitumor agent which shows potent cytotoxic activity[1][2].

 Names

Name 11-hydroxy-canthin-6-one
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.55g/cm3
Boiling Point 569.7ºC at 760mmHg
Melting Point 327-329 ºC
Molecular Formula C14H8N2O2
Molecular Weight 236.22600
Flash Point 298.3ºC
Exact Mass 236.05900
PSA 54.60000
LogP 2.14430
InChIKey IZNXKZBIIFOWPU-UHFFFAOYSA-N
SMILES O=c1cccc2c1c1cc[nH]c3ccc(=O)n2c31
Water Solubility Very slightly soluble (0.61 g/L) (25 ºC)

 11-Hydroxycanthin-6-oneBioassay

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Name: Primary cell-based high-throughput screening assay for identification of compounds th...
Source: Johns Hopkins Ion Channel Center
Target: regulator of G-protein signaling 4 isoform 2 [Homo sapiens]
External Id: JHICC_RGS_Act_HTS
Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN
Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
Name: uHTS identification of small molecule activators of the adaptive arm of the Unfolded ...
Source: Burnham Center for Chemical Genomics
Target: N/A
External Id: BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay
Name: Fluorescence polarization to screen for inhibitor that competite the binding of FadD2...
Source: Broad Institute
Target: FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE)
External Id: 2147-01_Inhibitor_SinglePoint_HTS_Activity
Name: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect...
Source: Broad Institute
Target: N/A
External Id: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity
Name: Counterscreen for inhibitors of the Steroid Receptor Coactivator 1 (SRC1; NCOA1): Lum...
Source: The Scripps Research Institute Molecular Screening Center
Target: transactivating tegument protein VP16 [Human herpesvirus 1]
External Id: VP16_INH_LUMI_1536_3X%INH CSRUN for SRC1
Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN
Name: Luminescence-based cell-based high throughput confirmation assay for inhibitors of th...
Source: The Scripps Research Institute Molecular Screening Center
Target: nuclear receptor coactivator 1 isoform 1 [Homo sapiens]
External Id: SRC1_INH_LUMI_1536_3X%INH CRUN
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 Synonyms

CANTHIN-6-ONE,11-HYDROXY
Amalorin
HMS2268C24
11-Hydroxycanthin-6-one
11-Hydroxy-6H-indolo[3,2,1-de][1,5]naphthyridin-6-one
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