苦木素

• 常用名: 苦木素
• 英文名: Quassin
• CAS号: 76-78-8
• 分子量: 388.454
• 密度: 1.2±0.1 g/cm3
• 沸点: 586.3±50.0 °C at 760 mmHg
• 分子式: C₂₂H₂₈O₆
• 熔点: 200 - 222ºC
• 闪点: 255.4±30.2 °C

苦木素用途

Quassin (Nigakilactone D) 是一种从 Quassia amara 的茎皮提取物中提取的生物活性三萜。Quassin 抑制 P. falciparum,IC50 为 0.15 μM。Quassin 具有可逆的抗生育能力,抗雌激素和抗疟原虫活性。

苦木素名称

• 中文名: 苦木素
• 英文名: quassin
• 中文别名: 苦味素

苦木素生物活性

• 描述: Quassin (Nigakilactone D) 是一种从 Quassia amara 的茎皮提取物中提取的生物活性三萜。Quassin 抑制 P. falciparum,IC50 为 0.15 μM。Quassin 具有可逆的抗生育能力,抗雌激素和抗疟原虫活性。
• 相关类别:
  研究领域 >> 内分泌
  研究领域 >> 感染
• 靶点实验:

  IC50: 0.15 μM (P. falciparum)[2]

• 体外研究: 类星体(化合物1；5-25 ng/mL)以剂量依赖的方式抑制大鼠睾丸间质细胞的基础和黄体生成激素刺激的睾酮分泌[3]。
• 体内研究: 拟青霉素(0.1-2.0 mg/kg；口服；每日；60天；雌性白化大鼠)治疗显示卵巢和子宫重量显著减轻。同时也显示类星体治疗的大鼠血清雌激素水平显著降低。类星体处理的大鼠平均产仔数和体重显著下降。类星体对大鼠的肾脏、心脏、肝脏和身体的重量没有负面影响[1]。动物模型：35只雌性白化大鼠(150-170 g)[1]剂量：0.1 mg/kg、1.0 mg/kg、2.0 mg/kg；口服；每日；60天结果：各组大鼠卵巢、子宫重量均较对照组明显减轻。类星体处理的大鼠血清雌激素水平也显著降低。
• 参考文献:

  [1]. Raji Y, et al. Reproductive activities of female albino rats treated with quassin, a bioactive triterpenoid from stem bark extract of Quassia amara. Niger J Physiol Sci. 2010 Nov 24;25(2):95-102.

  [2]. Mishra K, et al. Plasmodium falciparum: in vitro interaction of quassin and neo-quassin with artesunate, a hemisuccinate derivative of artemisinin. Exp Parasitol. 2010 Apr;124(4):421-7.

  [3]. Njar VC, et al. Antifertility activity of Quassia amara: quassin inhibits the steroidogenesis in rat Leydig cells in vitro. Planta Med. 1995 Apr;61(2):180-2.

苦木素物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 586.3±50.0 °C at 760 mmHg
• 熔点: 200 - 222ºC
• 分子式: C₂₂H₂₈O₆
• 分子量: 388.454
• 闪点: 255.4±30.2 °C
• 精确质量: 388.188599
• PSA: 78.90000
• LogP: 2.22
• InChIKey: IOSXSVZRTUWBHC-UHFFFAOYSA-N
• SMILES: COC1=CC(C)C2CC3OC(=O)CC4C(C)=C(OC)C(=O)C(C2(C)C1=O)C34C
• 外观性状: 粉末
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.553
• 储存条件: 2-8℃

苦木素安全信息

• 危害码 (欧洲): Xi

苦木素靶点实验

查看更多实验

实验名称：Inhibition of protein synthesis in human HeLa cells assessed as [35S]methionine incor... 来源：ChEMBL 靶标：HeLa External Id：CHEMBL1063015

实验名称：Growth inhibition of human NCI60 cells 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL1063016

实验名称：Inhibition of protein synthesis in cell-free extract of mouse Krebs2 cells by SDS-PAG... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1063014

实验名称：ERK5 transcriptional activity HTS 来源：24565 靶标：N/A External Id：ERK5 transcriptional activity-HTS

实验名称：Inhibition of H2O2-induced apoptosis in human SH-SY5Y cells assessed as viable cells ... 来源：ChEMBL 靶标：SH-SY5Y External Id：CHEMBL4482223

实验名称：Inhibition of H2O2-induced apoptosis in human SH-SY5Y cells assessed as late apoptoti... 来源：ChEMBL 靶标：SH-SY5Y External Id：CHEMBL4482225

实验名称：Inhibition of H2O2-induced apoptosis in human SH-SY5Y cells assessed as early apoptot... 来源：ChEMBL 靶标：SH-SY5Y External Id：CHEMBL4482224

实验名称：Cytotoxicity against human KB cells by microplate method 来源：ChEMBL 靶标：KB External Id：CHEMBL993817

实验名称：Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimo... 来源：ChEMBL 靶标：Solute carrier organic anion transporter family member 1B3 External Id：CHEMBL3039491

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

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苦木素英文别名

• Einecs 200-985-9
• 2,12-Dimethoxypicrasa-2,12-diene-1,11,16-trione
• Quassin,mixture of isomers w/Neoquassin and Isoquassin
• 11,16-trione,2,12-dimethoxy-picrasa-12-diene-1
• Picrasa-2,12-diene-1,11,16-trione,2,12-dimethoxy
• Nigakilactone D
• Quassin
• (3aR,6aR,7aS,8S,11aS,11bS,11cS)-2,10-Dimethoxy-3,8,11a,11c-tetramethyl-3a,6a,7,7a,8,11a,11b,11c-octahydrodibenzo[de,g]chromene-1,5,11(4H)-trione
• 3ab,6ab,7,7aa,8,11a,11ba,11c-Octahydro-2,10-dimethoxy-3,8a,11ab,11cb-tetramethylphenanthro[10,1-bc]pyran-1,5,11(4H)-trione