{2-[4-(2-氯-1,2-二苯基乙烯基)苯氧基]乙基}二乙胺 2-羟基-1,2,3-丙烷三羧酸

• 常用名: {2-[4-(2-氯-1,2-二苯基乙烯基)苯氧基]乙基}二乙胺 2-羟基-1,2,3-丙烷三羧酸
• 英文名: Zuclomiphene (citrete)
• CAS号: 7619-53-6
• 分子量: 598.08300
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₂H₃₆ClNO₈
• 熔点: N/A
• 闪点: N/A

用途

Zuclomiphene citrate 是柠檬酸克罗米芬的顺式异构体。Zuclomiphene citrate 具有抗雌激素的作用,比反式异构体更能抑制黄体生成激素 (LH) 的分泌。Zuclomiphene citrate 也是一种口服活性降胆固醇药。

名称

• 中文名: {2-[4-(2-氯-1,2-二苯基乙烯基)苯氧基]乙基}二乙胺 2-羟基-1,2,3-丙烷三羧酸
• 英文名: Clomiphene citrate, cis

生物活性

• 描述: Zuclomiphene citrate 是柠檬酸克罗米芬的顺式异构体。Zuclomiphene citrate 具有抗雌激素的作用,比反式异构体更能抑制黄体生成激素 (LH) 的分泌。Zuclomiphene citrate 也是一种口服活性降胆固醇药。
• 相关类别:
  信号通路 >> 其他 >> 雌激素受体/ERR
  研究领域 >> 内分泌
  研究领域 >> 代谢疾病
• 靶点实验:

  Estrogen Receptor/ERR

• 参考文献:

  [1]. Fontenot GK, et al. Differential effects of isomers of clomiphene citrate on reproductive tissues in male mice. BJU Int. 2016 Feb;117(2):344-50.

  [2]. Mikkelson TJ, et al. Single-dose pharmacokinetics of clomiphene citrate in normal volunteers. Fertil Steril. 1986 Sep;46(3):392-6.

  [3]. Sutherland RL. Estrogen antagonists in chick oviduct: antagonist activity of eight synthetic triphenylethylene derivatives and their interactions with cytoplasmic and nuclear estrogen receptors. Endocrinology. 1981 Dec;109(6):2061-8.

  [4]. Ramsey RB, et al. The biochemical and morphological response of hydrolytic enzymes in the developing brain to hypocholesterolemic agents. Acta Neuropathol. 1980;49(2):89-94.

物理化学性质

• 分子式: C₃₂H₃₆ClNO₈
• 分子量: 598.08300
• 精确质量: 597.21300
• PSA: 144.60000
• LogP: 5.31410
• InChIKey: PYTMYKVIJXPNBD-OQKDUQJOSA-N
• SMILES: CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1.O=C(O)CC(O)(CC(=O)O)C(=O)O
• 外观性状: 固体
• 储存条件: 2-8°C

毒性和生态

靶点实验

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英文别名

• cis-6,cis-11-Methyl-octadecadienoat
• cis-clomiphene citrate
• clomphencitrate
• cis-cis-6,11-Octadecadiensaeuremethylester
• Methyl-cis,cis-octadeca-6,11-dienoat
• cis,cis-Octadeca-6,11-diensaeure-methylester
• clomifen citrate
• I-Dihydrocitrat
• zuclomiphene citrate