大戟因子L1

• 常用名: 大戟因子L1
• 英文名: Euphorbia factor L1
• CAS号: 76376-43-7
• 分子量: 552.655
• 密度: 1.2±0.1 g/cm3
• 沸点: 633.1±55.0 °C at 760 mmHg
• 分子式: C₃₂H₄₀O₈
• 熔点: N/A
• 闪点: 263.9±31.5 °C

大戟因子L1用途

Euphorbia Factor L1 是续随子中的二萜类化合物,可降低 Bcl-2,PI3K,AKT 和 mTOR 蛋白和 mRNA 水平,上调 caspase-9 and caspase-3 蛋白水平,但对 caspase-9 和 caspase-3 蛋白酶原无影响。Euphorbia Factor L1 可诱导自噬 (apoptosis),具有抗癌、抗脂肪生成、抗破骨细胞生成和多重耐药调节作用。

大戟因子L1名称

• 中文名: 大戟因子L1
• 英文名: 5-Phosphononorvaline

大戟因子L1生物活性

• 描述: Euphorbia Factor L1 是续随子中的二萜类化合物,可降低 Bcl-2,PI3K,AKT 和 mTOR 蛋白和 mRNA 水平,上调 caspase-9 and caspase-3 蛋白水平,但对 caspase-9 和 caspase-3 蛋白酶原无影响。Euphorbia Factor L1 可诱导自噬 (apoptosis),具有抗癌、抗脂肪生成、抗破骨细胞生成和多重耐药调节作用。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Zhu A, et al. Effect of euphorbia factor L1 on oxidative stress, apoptosis, and autophagy in human gastric epithelial cells. Phytomedicine. 2019 Apr 16;64:152929.

大戟因子L1物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 633.1±55.0 °C at 760 mmHg
• 分子式: C₃₂H₄₀O₈
• 分子量: 552.655
• 闪点: 263.9±31.5 °C
• 精确质量: 552.272339
• PSA: 108.50000
• LogP: 5.55
• InChIKey: SDGDWRYYHQOQOJ-JGTACXIJSA-N
• SMILES: CC(=O)OC1C2C(OC(=O)Cc3ccccc3)C(C)CC2(OC(C)=O)C(=O)C(C)=CC2C(CCC13CO3)C2(C)C
• 蒸汽压: 0.0±1.9 mmHg at 25°C
• 折射率: 1.566
• 储存条件: 2-8°C

大戟因子L1靶点实验

查看更多实验

实验名称：Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL1059786

实验名称：Reversal of p-gp-mediated multidrug-resistance in human MCF7/ADM cells assessed as en... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1059787

实验名称：Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL5157857

实验名称：Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-indu... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL4481795

实验名称：Octanol-water partition coefficient, log P of the compound 来源：ChEMBL 靶标：N/A External Id：CHEMBL1059790

实验名称：Reversal of p-gp-mediated multidrug-resistance in human MCF7/ADM cells after 48 hrs b... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1059788

实验名称：Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability aft... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL4481796

实验名称：Reversal of P-gp-mediated multidrug resistance in human MCF/ADR cells assessed as rev... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1059789

共8条，当前第1页，共1页

1

大戟因子L1英文别名

• EUPATOROXIN,10-EPI
• Euphorbia Factor L1
• Benzeneacetic acid, (1aR,4aR,6S,7S,7aR,8S,9R,11aS)-4a,8-bis(acetyloxy)-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-4-oxospiro[9H-cyclopenta[a]cyclopropa[f]cycloundecene-9,2'-oxiran]-7-yl ester
• (1aR,2Z,4aR,6S,7S,7aR,8R,9S,11aS)-4a,8-Diacetoxy-1,1,3,6-tetramethyl-4-oxo-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydrospiro[cyclopenta[a]cyclopropa[f][11]annulene-9,2'-oxiran]-7-yl phenylacetate
• Benzeneacetic acid, (1aR,2Z,4aR,6S,7S,7aR,8R,9S,11aS)-4a,8-bis(acetyloxy)-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-4-oxospiro[9H-cyclopenta[a]cyclopropa[f]cycloundecene-9,2'-oxiran]-7-yl ester
• (1aR,4aR,6S,7S,7aR,8S,9R,11aS)-4a,8-Diacetoxy-1,1,3,6-tetramethyl-4-oxo-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydrospiro[cyclopenta[a]cyclopropa[f][11]annulene-9,2'-oxiran]-7-yl phenylacetate
• 10-epi-Eupatoroxin