GBR 12935

• 常用名: GBR 12935
• 英文名: GBR 12935
• CAS号: 76778-22-8
• 分子量: 414.58
• 密度: 1.067g/cm3
• 沸点: 540.6ºC at 760 mmHg
• 分子式: C₂₈H₃₄N₂O
• 熔点: N/A
• 闪点: 143.9ºC

GBR 12935用途

GBR 12935是多巴胺再吸收抑制剂。

GBR 12935名称

• 中文名: 1-(2-乙基)-4-(3-苯丙基)哌嗪,马来酸盐
• 英文名: 1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine

GBR 12935生物活性

• 描述: GBR 12935是多巴胺再吸收抑制剂。
• 相关类别:
  信号通路 >> 神经信号通路 >> 多巴胺转运蛋白
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Hiroi T, et al. Specific binding of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl propyl) piperazine (GBR-12935), an inhibitor of the dopamine transporter, to human CYP2D6. Biochem Pharmacol. 1997 Jun 15;53(12):1937-9.

  [2]. Rahman S, et al. Negative interaction of dopamine D2 receptor antagonists and GBR 12909 and GBR 12935 dopamine uptake inhibitors in the nucleus accumbens. Eur J Pharmacol. 2001 Feb 23;414(1):37-44.

  [3]. Tolliver BK, et al. Comparison of cocaine and GBR 12935: effects on locomotor activity and stereotypy in two inbred mouse strains. Pharmacol Biochem Behav. 1994 Jul;48(3):733-9.

GBR 12935物理化学性质

• 密度: 1.067g/cm3
• 沸点: 540.6ºC at 760 mmHg
• 分子式: C₂₈H₃₄N₂O
• 分子量: 414.58
• 闪点: 143.9ºC
• PSA: 90.31000
• LogP: 4.63060
• 折射率: 1.576
• 储存条件: 2-8℃

GBR 12935安全信息

• 海关编码: 2933599090

GBR 12935海关

• 海关编码: 2933599090
• 中文概述: 2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

GBR 12935英文别名

• 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (2Z)-but-2-enedioate (1:1)
• Piperazine, 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)-, (2Z)-2-butenedioate (1:1)
• 1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (2Z)-2-butenedioate (1:1)
• 1-(2-benzhydryloxy-ethyl)-4-(3-phenyl-propyl)-piperazine
• Piperazine,1-(2-(diphenylmethoxy)ethyl)-4-(3-phenylpropyl)
• N-[3-tert-Butyl-1-(4-Methylphenyl)-1H-pyrazol-5-yl]-N-[4-[2-(4-Morpholinyl)ethoxy]naphthalen-1-yl]urea
• 1-Hydrocinnamyl-4-[2-(diphenylmethoxy)ethyl]piperazine
• 1-(2-(diphenylmethoxy)-ethyl)-4-(3-phenylpropyl)piperazine
• 1-(2-(Benzhydryloxy)ethyl)-4-(3-phenylpropyl)piperazine maleate
• GBR 12935