CAY10434

• 常用名: CAY10434
• 英文名: CAY10434
• CAS号: 769917-29-5
• 分子量: 287.400
• 密度: 1.0±0.1 g/cm3
• 沸点: 435.0±30.0 °C at 760 mmHg
• 分子式: C₁₇H₂₆N₃O+
• 熔点: N/A
• 闪点: 216.9±24.6 °C

CAY10434用途

CAY 10434是一种强效的CYP4A羟化酶抑制剂。CAY 10434以6764 mg的最大收缩反应(Emax)改善对血管紧张素II的收缩反应[1]。

CAY10434名称

• 英文名: cay10434

CAY10434生物活性

• 描述: CAY 10434是一种强效的CYP4A羟化酶抑制剂。CAY 10434以6764 mg的最大收缩反应(Emax)改善对血管紧张素II的收缩反应[1]。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> 代谢酶/蛋白酶 >> 细胞色素P450
• 体外研究: 开孔10434(1µM；30分钟) 结合咪康唑可增加内皮完整主动脉环中血管紧张素 二、的累积[1]。
• 参考文献:

  [1]. Jerez S, et al. 17-Octadecynoic acid improves contractile response to angiotensin II by releasing vasocontrictor prostaglandins. Prostaglandins Other Lipid Mediat. 2012 Jan;97(1-2):36-42.

CAY10434物理化学性质

• 密度: 1.0±0.1 g/cm3
• 沸点: 435.0±30.0 °C at 760 mmHg
• 分子式: C₁₇H₂₆N₃O+
• 分子量: 287.400
• 闪点: 216.9±24.6 °C
• 精确质量: 287.199768
• PSA: 27.84000
• LogP: 3.33
• InChIKey: FIFQJYUSSPRJIZ-UHFFFAOYSA-N
• SMILES: CN(C)CCCCCCOc1ccc(-n2ccnc2)cc1
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.539
• 储存条件: -20°C

CAY10434靶点实验

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实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：A screen for small molecules that modulate mitochondrial supercomplex formation 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1482

实验名称：Distribution coefficient of compound was evaluated at pH 6.8 来源：ChEMBL 靶标：N/A External Id：CHEMBL631359

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

实验名称：Stabilization of p53 in human papillomavirus-positive cells 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Cellular tumor antigen p53 External Id：HMS1485

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CAY10434英文别名

• 6-[4-(1H-Imidazol-1-yl)phenoxy]-N,N-dimethyl-1-hexanamine
• 6-[4-(1H-imidazol-1-yl)phenoxy]-N,N-dimethylhexan-1-amine