6-O-甲基鸟苷

• 常用名: 6-O-甲基鸟苷
• 英文名: 6-O-Methyl Guanosine
• CAS号: 7803-88-5
• 分子量: 297.267
• 密度: 2.0±0.1 g/cm3
• 沸点: 721.0±70.0 °C at 760 mmHg
• 分子式: C₁₁H₁₅N₅O₅
• 熔点: N/A
• 闪点: 389.9±35.7 °C

6-O-甲基鸟苷用途

6-O-Methyl Guanosine 是一种修饰的核苷。6-O-Methyl Guanosine (6-methylguanosine) 作用于恶性着色性干皮病细胞系,抑制集落形成。

6-O-甲基鸟苷名称

• 中文名: 6-O-甲基鸟苷
• 英文名: (2R,3S,4R,5R)-2-(2-amino-6-methoxypurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

6-O-甲基鸟苷生物活性

• 描述: 6-O-Methyl Guanosine 是一种修饰的核苷。6-O-Methyl Guanosine (6-methylguanosine) 作用于恶性着色性干皮病细胞系,抑制集落形成。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Grasby JA, et al. The synthesis of oligoribonucleotides containing O6-methylguanosine: the role of conserved guanosine residues in hammerhead ribozyme cleavage. Nucleic Acids Res. 1993 Sep 25;21(19):4444-50.

  [2]. Thielmann HW, et al. 6-Methylguanine and 6-methylguanosine inhibit colony-forming ability in a malignant xeroderma pigmentosum cell line but not in other xeroderma pigmentosum and normal human fibroblast strains after treatment with 1-(2-chloroethyl)-1-nitroso-3-(2-hydroxyethyl)-urea. J Cancer Res Clin Oncol. 1987;113(1):67-72.

6-O-甲基鸟苷物理化学性质

• 密度: 2.0±0.1 g/cm3
• 沸点: 721.0±70.0 °C at 760 mmHg
• 分子式: C₁₁H₁₅N₅O₅
• 分子量: 297.267
• 闪点: 389.9±35.7 °C
• 精确质量: 297.107330
• PSA: 148.77000
• LogP: -0.58
• InChIKey: IXOXBSCIXZEQEQ-KQYNXXCUSA-N
• SMILES: COc1nc(N)nc2c1ncn2C1OC(CO)C(O)C1O
• 蒸汽压: 0.0±2.4 mmHg at 25°C
• 折射率: 1.829
• 储存条件: 2-8℃

6-O-甲基鸟苷毒性和生态

6-O-甲基鸟苷靶点实验

查看更多实验

实验名称：Drug screen in LFS_MB_P medulloblastoma cells to determine synergistic drug combinati... 来源：25008 靶标：N/A External Id：DKFZ_drug_screen_chromothripsis_LFS_MB_P

实验名称：Drug screen in ICB984 medulloblastoma cells to determine synergistic drug combination... 来源：25008 靶标：N/A External Id：DKFZ_drug_screen_chromothripsis_ICB984_MB

实验名称：Activity of recombinant human ADAL1 expressed in Escherichia coli by UV-spectrophotom... 来源：ChEMBL 靶标：Adenosine deaminase-like protein External Id：CHEMBL1817386

实验名称：Drug screen in HDN33 neuroblastoma cells to determine synergistic drug combinations t... 来源：25008 靶标：N/A External Id：DKFZ_drug_screen_chromothripsis_HDN33

实验名称：Drug screen in HD-MB03 medulloblastoma cells to determine synergistic drug combinatio... 来源：25008 靶标：N/A External Id：DKFZ_drug_screen_chromothripsis_HD-MB03

实验名称：Drug screen in CRL2098 osteosarcoma cells to determine synergistic drug combinations ... 来源：25008 靶标：N/A External Id：DKFZ_drug_screen_chromothripsis_CRL2098

实验名称：Inhibition of cytopathic effect in Bacillus anthracis Sterne infected mouse RAW264.7 ... 来源：ChEMBL 靶标：Bacillus anthracis External Id：CHEMBL925842

实验名称：Inhibition of inosine/L-alanine-induced Bacillus anthracis Sterne 34F2 spore germinat... 来源：ChEMBL 靶标：Bacillus anthracis External Id：CHEMBL1690567

实验名称：ASTRAZENECA: Octan-1-ol/water (pH7.4) distribution coefficent measured by a shake fl... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3301363

实验名称：Antibacterial activity against Bacillus anthracis Sterne 34F2 infected in mouse J774A... 来源：ChEMBL 靶标：Bacillus anthracis External Id：CHEMBL1690568

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6-O-甲基鸟苷英文别名

• 6-O-METHYLGUANOSINE
• Guanosine,o-methyl
• 2-amino-6-methoxypurine riboside
• 6-Methoxy-6-deoxoguanosine
• o-methoxydeoxyguanosine
• O-Methylguanosine
• 6-Methoxy-9-(β-D-ribofuranosyl)-9H-purin-2-amine
• O6-METHYLGUANOSINE
• o-methyl-guanosin
• 2-Amino-6-methoxypurine Ribonucleoside