7803-88-5

• 常用中文名：6-O-甲基鸟苷
• 常用英文名：6-O-Methyl Guanosine
• CAS号：7803-88-5
• 分子式：C₁₁H₁₅N₅O₅
• 分子量：297.267
• 相关类别： 信号通路 细胞周期/DNA损伤 核苷抗代谢药/类似物
• 发布时间：2017-10-22 09:51:32
• 更新时间：2024-01-06 10:22:18
• 6-O-Methyl Guanosine 是一种修饰的核苷。6-O-Methyl Guanosine (6-methylguanosine) 作用于恶性着色性干皮病细胞系，抑制集落形成。

名称

• 中文名: 6-O-甲基鸟苷
• 英文名: (2R,3S,4R,5R)-2-(2-amino-6-methoxypurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
• 英文别名: 9H-Purin-2-amine, 6-methoxy-9-β-D-ribofuranosyl-; 6-O-METHYLGUANOSINE; Guanosine,o-methyl; 2-amino-6-methoxypurine riboside; 6-Methoxy-6-deoxoguanosine; o-methoxydeoxyguanosine; O-Methylguanosine; 6-Methoxy-9-(β-D-ribofuranosyl)-9H-purin-2-amine; O6-METHYLGUANOSINE; o-methyl-guanosin; 2-Amino-6-methoxypurine Ribonucleoside

物化性质

• 密度: 2.0±0.1 g/cm3
• 沸点: 721.0±70.0 °C at 760 mmHg
• 分子式: C₁₁H₁₅N₅O₅
• 分子量: 297.267
• 闪点: 389.9±35.7 °C
• 精确质量: 297.107330
• PSA: 148.77000
• LogP: -0.58
• 蒸汽压: 0.0±2.4 mmHg at 25°C
• 折射率: 1.829
• 储存条件: 2-8℃

生物活性

• 描述: 6-O-Methyl Guanosine 是一种修饰的核苷。6-O-Methyl Guanosine (6-methylguanosine) 作用于恶性着色性干皮病细胞系,抑制集落形成。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Grasby JA, et al. The synthesis of oligoribonucleotides containing O6-methylguanosine: the role of conserved guanosine residues in hammerhead ribozyme cleavage. Nucleic Acids Res. 1993 Sep 25;21(19):4444-50.

  [2]. Thielmann HW, et al. 6-Methylguanine and 6-methylguanosine inhibit colony-forming ability in a malignant xeroderma pigmentosum cell line but not in other xeroderma pigmentosum and normal human fibroblast strains after treatment with 1-(2-chloroethyl)-1-nitroso-3-(2-hydroxyethyl)-urea. J Cancer Res Clin Oncol. 1987;113(1):67-72.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : MF8790000 CHEMICAL NAME : Guanosine, O-methyl- CAS REGISTRY NUMBER : 7803-88-5 LAST UPDATED : 199612 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C11-H15-N5-O5 MOLECULAR WEIGHT : 297.31 WISWESSER LINE NOTATION : T56 BN DN FVN INJ HZ B- BT5OTJ CO1 DQ E1Q HEALTH HAZARD DATA ACUTE TOXICITY DATA MUTATION DATA TYPE OF TEST : DNA damage TEST SYSTEM : Rodent - hamster Lung DOSE/DURATION : 2400 nmol/L REFERENCE : ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 4,321,1982

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