![N-甲基-9H-吡啶[3,4-b]吲哚-3-甲酰胺结构式](https://www.chemsrc.com/caspic/334/78538-74-6.png)
N-甲基-9H-吡啶[3,4-b]吲哚-3-甲酰胺结构式
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常用名 | N-甲基-9H-吡啶[3,4-b]吲哚-3-甲酰胺 | 英文名 | FG 7142 |
|---|---|---|---|---|
| CAS号 | 78538-74-6 | 分子量 | 225.24600 | |
| 密度 | 1.328g/cm3 | 沸点 | 576.3ºC at 760 mmHg | |
| 分子式 | C13H11N3O | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | 302.3ºC |
N-甲基-9H-吡啶[3,4-b]吲哚-3-甲酰胺用途
本网站展示的所有产品仅用作科学研究，不可食用，不可用于人体或动物的临床诊断和治疗。
FG 7142 (ZK 39106; LSU-65) 是一种非选择性的苯二氮杂卓反向激动剂,对含 α1 亚基的 GABAA receptor 具有高亲和力 (Ki= 91 nM)。FG 7142 (ZK 39106; LSU-65) 还调节表达 α1 亚基的 GABAA 受体上 GABA 诱导的氯通量 (EC50= 137 nM)。FG 7142 (ZK 39106; LSU-65) 可以增加酪氨酸羟化并导致小鼠大脑皮层中 β-肾上腺素受体的上调。 |
| 中文名 | N-甲基-beta-咔啉-3-羧酰胺 |
|---|---|
| 英文名 | N-Methyl-b-carboline-3-carboxamide |
| 英文别名 | 更多 |
| 描述 | FG 7142 (ZK 39106; LSU-65) 是一种非选择性的苯二氮杂卓反向激动剂,对含 α1 亚基的 GABAA receptor 具有高亲和力 (Ki= 91 nM)。FG 7142 (ZK 39106; LSU-65) 还调节表达 α1 亚基的 GABAA 受体上 GABA 诱导的氯通量 (EC50= 137 nM)。FG 7142 (ZK 39106; LSU-65) 可以增加酪氨酸羟化并导致小鼠大脑皮层中 β-肾上腺素受体的上调。 |
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| 相关类别 | |
| 体外研究 | FG-7142对α亚基的表达具有亲和力,α1、α2、α3和α5亚基的Ki值分别为91nm、330nm、492nm和2.150μM[1]。FG-7142在表达α1亚基(EC50=137nm)的GABA a受体处调节GABA诱导的氯离子通量方面比其他α亚基(EC50:α2=507nm,α3=1.021μM,α5=1.439μM)有更高的效率[1]。 |
| 体内研究 | FG-7142(腹腔注射；15-30mg/kg)激活大鼠大脑中边缘皮质多巴胺能投射,导致前额叶皮质和伏隔核多巴胺增加[1]。FG-7142(腹腔注射；15mg/kg)增加了体内前额叶内侧皮质和腹侧被盖的酪氨酸羟化酶活性和多巴胺周转率,但在中边缘或黑质纹状体区域没有发现影响[1]。 |
| 参考文献 |
| 密度 | 1.328g/cm3 |
|---|---|
| 沸点 | 576.3ºC at 760 mmHg |
| 分子式 | C13H11N3O |
| 分子量 | 225.24600 |
| 闪点 | 302.3ºC |
| 精确质量 | 225.09000 |
| PSA | 57.78000 |
| LogP | 2.46660 |
| 折射率 | 1.735 |
| 储存条件 | 2-8°C |
| 个人防护装备 | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| 危险品运输编码 | NONH for all modes of transport |
| WGK德国 | 3 |
| RTECS号 | UU9780100 |
| 海关编码 | 2933990090 |
|
~43%
N-甲基-9H-吡啶[3,4-... 78538-74-6 |
| 文献：A/S Ferrosan; Scherling AG Patent: US4371536 A1, 1983 ; US 4371536 A |
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N-甲基-9H-吡啶[3,4-... 78538-74-6 |
| 文献：Couts, Ronald T.; Micetich, Ronald G.; Baker, Glen B; Benderly, Abraham; Dewhurst, Tim; et al. Heterocycles, 1984 , vol. 22, # 1 p. 131 - 142 |
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~%
N-甲基-9H-吡啶[3,4-... 78538-74-6 |
| 文献：Couts, Ronald T.; Micetich, Ronald G.; Baker, Glen B; Benderly, Abraham; Dewhurst, Tim; et al. Heterocycles, 1984 , vol. 22, # 1 p. 131 - 142 |
|
~%
N-甲基-9H-吡啶[3,4-... 78538-74-6 |
| 文献：Couts, Ronald T.; Micetich, Ronald G.; Baker, Glen B; Benderly, Abraham; Dewhurst, Tim; et al. Heterocycles, 1984 , vol. 22, # 1 p. 131 - 142 |
|
~%
N-甲基-9H-吡啶[3,4-... 78538-74-6 |
| 文献：Manabe, Shigeo; Juan, Yuan; Wada, Osamu; Ueki, Akira; Kanai, Yoshikatsu Environmental Pollution (Amsterdam, Netherlands), 1995 , vol. 89, # 3 p. 329 - 336 |
|
~%
N-甲基-9H-吡啶[3,4-... 78538-74-6 |
| 文献：Manabe, Shigeo; Juan, Yuan; Wada, Osamu; Ueki, Akira; Kanai, Yoshikatsu Environmental Pollution (Amsterdam, Netherlands), 1995 , vol. 89, # 3 p. 329 - 336 |
|
~%
N-甲基-9H-吡啶[3,4-... 78538-74-6 |
| 文献：Manabe, Shigeo; Juan, Yuan; Wada, Osamu; Ueki, Akira; Kanai, Yoshikatsu Environmental Pollution (Amsterdam, Netherlands), 1995 , vol. 89, # 3 p. 329 - 336 |
|
~%
N-甲基-9H-吡啶[3,4-... 78538-74-6 |
| 文献：Lin, Guowu; Wang, Yue; Zhou, Qingfa; Tang, Weifang; Wang, Jian; Lu, Tao Molecules, 2010 , vol. 15, # 8 p. 5680 - 5691 |
| N-甲基-9H-吡啶[3,4-b]吲哚-3-甲酰胺上游产品 10 | |
|---|---|
| N-甲基-9H-吡啶[3,4-b]吲哚-3-甲酰胺下游产品 0 | |
| 海关编码 | 2933990090 |
|---|---|
| 中文概述 | 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0% |
| 申报要素 | 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期 |
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Performance in anxiety and spatial memory tests following bilateral vestibular loss in the rat and effects of anxiolytic and anxiogenic drugs.
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| B-carboline-3-carboxylic acid N-*methylamide |
| FG 7142 |
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