MAO-B-IN-27

• 常用名: MAO-B-IN-27
• 英文名: MAO-B-IN-27
• CAS号: 788824-83-9
• 分子量: 331.76
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₆H₁₇ClF₃NO
• 熔点: N/A
• 闪点: N/A

MAO-B-IN-27用途

MAO-B-IN-27 (Compound 12c) 是一种单胺氧化酶 B (MAO-B) 抑制剂。 MAO-B-IN-27 对 hMAO-B 具有有效且选择性的 MAO-B 抑制作用,IC50 值为 8.9 nM。 MAO-B-IN-27 可用于帕金森病 (PD) 的研究。

MAO-B-IN-27名称

• 英文名: MAO-B-IN-27

MAO-B-IN-27生物活性

• 描述: MAO-B-IN-27 (Compound 12c) 是一种单胺氧化酶 B (MAO-B) 抑制剂。 MAO-B-IN-27 对 hMAO-B 具有有效且选择性的 MAO-B 抑制作用,IC50 值为 8.9 nM。 MAO-B-IN-27 可用于帕金森病 (PD) 的研究。
• 相关类别:
  信号通路 >> 神经信号通路 >> 单胺氧化酶
  研究领域 >> 神经疾病
• 靶点实验:

  IC50: 8.9 nM (hMAO-B)[1].

• 参考文献:

  [1]. Yeon SK, et al. Synthesis and evaluation of biaryl derivatives for structural characterization of selective monoamine oxidase B inhibitors toward Parkinson's disease therapy. Bioorg Med Chem. 2018 Jan 1;26(1):232-244.

MAO-B-IN-27物理化学性质

• 分子式: C₁₆H₁₇ClF₃NO
• 分子量: 331.76

MAO-B-IN-27靶点实验

查看更多实验

实验名称：Selectivity index, ratio of IC50 for recombinant human MAO-A to IC50 for recombinant ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4182526

实验名称：Competitive inhibition of recombinant human MAO-B assessed as Vmax for substrate usin... 来源：ChEMBL 靶标：Amine oxidase [flavin-containing] B External Id：CHEMBL4182527

实验名称：Inhibition of recombinant human MAO-B using benzylamine as substrate preincubated for... 来源：ChEMBL 靶标：Amine oxidase [flavin-containing] B External Id：CHEMBL4182524

实验名称：Inhibition of recombinant human MAO-A using p-tyramine as substrate preincubated for ... 来源：ChEMBL 靶标：Amine oxidase [flavin-containing] A External Id：CHEMBL4182525

实验名称：Anti-parkinson's activity in MPTP-induced C57Bl/6 mouse model of Parkinson's disease ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4182534

实验名称：Anti-parkinson's activity in MPTP-induced C57Bl/6 mouse model of Parkinson's disease ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4182530

实验名称：Anti-parkinson's activity in MPTP-induced C57Bl/6 mouse model of Parkinson's disease ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4182531

实验名称：Anti-parkinson's activity in MPTP-induced C57Bl/6 mouse model of Parkinson's disease ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4182532

实验名称：Restoration of MPTP-induced tyrosine hydroxylase enzyme activity loss in C57Bl/6 mous... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4182533

共9条，当前第1页，共1页

1