BI-6C9

更新时间：2024-01-02 15:45:26

BI-6C9结构式	常用名	BI-6C9	英文名	BI-6C9
	CAS号	791835-21-7	分子量	471.59200
	密度	1.368g/cm3	沸点	N/A
	分子式	C₂₃H₂₅N₃O₄S₂	熔点	N/A
	MSDS	中文版美版	闪点	N/A

BI-6C9用途

BI-6C9 是一种 BH3 相互作用结构域 (Bid) 抑制剂,可阻止线粒体外膜电位 (MOMP) 和线粒体分裂,并保护细胞免受死亡。

英文名	N-[4-(4-aminophenyl)sulfanylphenyl]-4-[(4-methoxyphenyl)sulfonylamino]butanamide
英文别名	更多

描述	BI-6C9 是一种 BH3 相互作用结构域 (Bid) 抑制剂,可阻止线粒体外膜电位 (MOMP) 和线粒体分裂,并保护细胞免受死亡。
相关类别	信号通路 >> 代谢酶/蛋白酶 >> 线粒体代谢研究领域 >> 神经疾病
参考文献	[1]. Grohm J, et al. Bid mediates fission, membrane permeabilization and peri-nuclear accumulation of mitochondria as a prerequisite for oxidative neuronal cell death. Brain Behav Immun. 2010 Jul;24(5):831-8.

密度	1.368g/cm3
分子式	C₂₃H₂₅N₃O₄S₂
分子量	471.59200
精确质量	471.12900
PSA	144.20000
LogP	6.25170
折射率	1.671
储存条件	-20°C，密闭，干燥

BI-6C9MSDS英文版

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危险品运输编码	NONH for all modes of transport
WGK德国	3

Differential effects of ethanol on bid, tBid, and Bax:tBid interactions in postnatal day 4 and postnatal day 7 rat cerebellum.

Alcohol. Clin. Exp. Res. 39(1) , 55-63, (2015)

Exposure to ethanol (EtOH) during central nervous system (CNS) development can lead to a wide array of neuroanatomical, behavioral, and cognitive abnormalities, broadly subsumed under the fetal alcoho...

Momordica charantia lectin exhibits antitumor activity towards hepatocellular carcinoma.

Invest. New Drugs 33(1) , 1-11, (2015)

The incidence and mortality of hepatocellular carcinoma (HCC) remain high worldwide. Drug screening from natural plants is one of the potential therapeutic approaches on HCC.The antitumor effect of mo...

Novel N-phenyl-substituted thiazolidinediones protect neural cells against glutamate- and tBid-induced toxicity.

J. Pharmacol. Exp. Ther. 350(2) , 273-89, (2014)

Mitochondrial demise is a key feature of progressive neuronal death contributing to acute and chronic neurological disorders. Recent studies identified a pivotal role for the BH3-only protein B-cell l...

N-[4-[(4-Aminophenyl)thio]phenyl]-4-[[(4-methoxyphenyl)sulfonyl]amino]-Butanamide

BI-6C9