酚加宾

• 常用名: 酚加宾
• 英文名: Fengabine
• CAS号: 80018-06-0
• 分子量: 322.22900
• 密度: 1.24g/cm3
• 沸点: 442.2ºC at 760 mmHg
• 分子式: C₁₇H₁₇Cl₂NO
• 熔点: N/A
• 闪点: 221.2ºC

酚加宾用途

芬加宾是一种GABA能抗抑郁药物。Fengabine可用于抑郁症的研究[1]。

酚加宾名称

• 中文名: 酚加宾
• 英文名: (6Z)-6-[butylamino-(2-chlorophenyl)methylidene]-4-chlorocyclohexa-2,4-dien-1-one

酚加宾生物活性

• 描述: 芬加宾是一种GABA能抗抑郁药物。Fengabine可用于抑郁症的研究[1]。
• 相关类别:
  信号通路 >> 跨膜转运 >> GABA受体
  研究领域 >> 神经疾病
  信号通路 >> 神经信号通路 >> GABA受体
• 体内研究: 芬加宾(50毫克/千克；i、 p。；2天)完全防止不可避免的电击引起的习得性无助[1]。芬加宾(150毫克/千克；i、 p)减少所花费时间的百分比。芬加宾(25～50mg/kg；i、 p.)逆转学习跳台回避任务的缺陷[1]。动物模型：大鼠剂量：50mg/kg给药：I.p.结果：完全预防了不可避免的休克引起的习得性无助感。
• 参考文献:

  [1]. Ascalone V, et al. Determination of the GABAergic antidepressant drug fengabine and some of its metabolites in plasma by capillary gas chromatography with electron-capture detection. J Chromatogr. 1989;490(1):81-90.

  [2]. Lloyd KG, et al. Fengabine, a novel antidepressant GABAergic agent. I. Activity in models for antidepressant drugs and psychopharmacological profile. J Pharmacol Exp Ther. 1987;241(1):245-250.

酚加宾物理化学性质

• 密度: 1.24g/cm3
• 沸点: 442.2ºC at 760 mmHg
• 分子式: C₁₇H₁₇Cl₂NO
• 分子量: 322.22900
• 闪点: 221.2ºC
• 精确质量: 321.06900
• PSA: 32.59000
• LogP: 5.33650
• InChIKey: ZGLIFVFRIOKQLE-UHFFFAOYSA-N
• SMILES: CCCCN=C(c1cc(Cl)ccc1O)c1ccccc1Cl
• 折射率: 1.598

酚加宾毒性和生态

酚加宾靶点实验

查看更多实验

实验名称：Moderate liver toxicity, defined via clinical-chemistry results: ALT or AST serum act... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3137722

实验名称：Highest frequency of moderate liver toxicity observed during clinical trials, express... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3137723

实验名称：Acute liver toxicity defined via clinical observations and clear clinical-chemistry r... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3137724

实验名称：Highest frequency of acute liver toxicity observed during clinical trials, expressed ... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3137725

实验名称：Cytolytic liver toxicity, either proven histopathologically or where the ratio of max... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3137726

实验名称：Choleostatic liver toxicity, either proven histopathologically or where the ratio of ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3137727

实验名称：Severe hepatitis, defined as possibly life-threatening liver failure or through clini... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3137728

实验名称：Chronic liver disease either proven histopathologically, or through a chonic elevatio... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3137729

实验名称：Cirrhosis, proven histopathologically. Value is number of references indexed. [column... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3137730

实验名称：Granulomatous liver disease, proven histopathologically. Value is number of reference... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3137731

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酚加宾英文别名

• SL 79-229
• FENGABINE
• Fengabinum
• Fengabina