大戟苷

• 常用名: 大戟苷
• 英文名: euphornin
• CAS号: 80454-47-3
• 分子量: 584.70
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₃H₄₄O₉
• 熔点: N/A
• 闪点: N/A

大戟苷用途

Euphorin是一种抗癌剂,可以从E.heloscopia中分离出来。幼发蛋白通过胱天蛋白酶介导的途径诱导细胞凋亡。幼发拉鸟蛋白通过增加磷酸化-CDK1(Tyr15)蛋白的水平诱导细胞周期停滞[1]。

大戟苷名称

• 中文名: 大戟苷
• 英文名: euphornin

大戟苷生物活性

• 描述: Euphorin是一种抗癌剂,可以从E.heloscopia中分离出来。幼发蛋白通过胱天蛋白酶介导的途径诱导细胞凋亡。幼发拉鸟蛋白通过增加磷酸化-CDK1(Tyr15)蛋白的水平诱导细胞周期停滞[1]。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  信号通路 >> 细胞凋亡 >> 胱天蛋白酶
• 体外研究: 幼发蛋白(50-200μg/mL,48小时)显著增加裂解的 半胱氨酸蛋白酶-3、半胱氨酸蛋白酶-8、半胱氨酸蛋白酶-9和 胱天蛋白酶-10的水平[1]
• 参考文献:

  [1]. Li XQ, et al. Euphornin reduces proliferation of human cervical adenocarcinoma HeLa cells through induction of apoptosis and G2/M cell cycle arrest. Onco Targets Ther. 2018 Jul 27;11:4395-4405.

大戟苷物理化学性质

• 分子式: C₃₃H₄₄O₉
• 分子量: 584.70
• 精确质量: 584.29900
• PSA: 125.43000
• LogP: 4.96270
• InChIKey: BRVXVMOWTHQKHC-NHTJSLHDSA-N
• SMILES: CC(=O)OC1CC(OC(C)=O)C(C)(C)C=CC(C)C(OC(C)=O)C2(O)CC(C)C(OC(=O)c3ccccc3)C2C=C1C

大戟苷靶点实验

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实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Primary Screen for Target Class Profiling of Small Molecule Inhibitors of Methyltrans... 来源：NCGC External Id：MTASE-p

实验名称：Inhibition of GIRK-1/4 channel (unknown origin) expressed in HEK293 cells at 10 uM by... 来源：ChEMBL 靶标：G protein-activated inward rectifier potassium channel 4 External Id：CHEMBL4270203

实验名称：Primary qHTS to identify gynecologic anti-cancer compounds using libraries of approve... 来源：NCGC 靶标：N/A External Id：OBG420

实验名称：Inhibition of GIRK-1/4 channel (unknown origin) expressed in HEK293 cells at 1 uM by ... 来源：ChEMBL 靶标：G protein-activated inward rectifier potassium channel 4 External Id：CHEMBL4270202

实验名称：Cytotoxicity against HEK293 cells assessed as reduction in cell proliferation at 30 u... 来源：ChEMBL 靶标：HEK293 External Id：CHEMBL5121924

实验名称：Inhibition of human ERG expressed in HEK293 cells at 1 uM by automated patch clamp me... 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily H member 2 External Id：CHEMBL4270205

实验名称：Inhibition of human Kv1.3 expressed in HEK293 cells assessed as inhibition of tetracy... 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily A member 3 External Id：CHEMBL5121925

实验名称：Inhibition of GIRK-1/4 channel (unknown origin) expressed in HEK293 cells by automate... 来源：ChEMBL 靶标：G protein-activated inward rectifier potassium channel 4 External Id：CHEMBL4270204

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i... 来源：NCGC External Id：NSD2-synergy-p-2C

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大戟苷英文别名

• Benzoic acid (6E,12E)-(1S,2S,3aR,4S,5S,9R,11R,13aS)-4,9,11-triacetoxy-3a-hydroxy-2,5,8,8,12-pentamethyl-2,3,3a,4,5,8,9,10,11,13a-decahydro-1H-cyclopentacyclododecen-1-yl ester