牛磺胆酸

• 常用名: 牛磺胆酸
• 英文名: Taurocholic Acid
• CAS号: 81-24-3
• 分子量: 571.81
• 密度: 1.265g/cm3
• 沸点: N/A
• 分子式: C₃₀H₅₃NO₇S
• 熔点: 125°C (rough estimate)
• 闪点: N/A

牛磺胆酸用途

Taurocholic acid 是一种胆汁酸,参与脂肪的乳化。

牛磺胆酸名称

• 中文名: N-(3Alpha,7Alpha,12Alpha)三羟基-5β-胆甾烷-24-酰基牛黄酸
• 英文名: Taurocholic Acid
• 中文别名: 牛黄胆酸 | N-(3α,7α,12α)三羟基-5β-胆甾烷-24-酰基牛黄酸 | 3α,7α,12α-三羟基-5β-胆甾烷-24-羧酸-24-牛黄酸酰胺

牛磺胆酸生物活性

• 描述: Taurocholic acid 是一种胆汁酸,参与脂肪的乳化。
• 相关类别:
  研究领域 >> 炎症/免疫
  天然产物 >> 类固醇
• 靶点实验:

  Human Endogenous Metabolite

• 体内研究: 胆汁酸Taurocholic acid(TCA)在体内发挥渗透增强作用[1]。
• 参考文献:

  [1]. Mooranian A, et al. The effect of a tertiary bile acid, taurocholic acid, on the morphology and physical characteristics of microencapsulated probucol: potential applications in diabetes: a characterization study. Drug Deliv Transl Res. 2015 Oct;5(5):511-22.

牛磺胆酸物理化学性质

• 密度: 1.265g/cm3
• 熔点: 125°C (rough estimate)
• 分子式: C₃₀H₅₃NO₇S
• 分子量: 571.81
• PSA: 152.54000
• LogP: 3.83980
• InChIKey: WBWWGRHZICKQGZ-HZAMXZRMSA-N
• SMILES: CC(CCC(=O)NCCS(=O)(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C
• 外观性状: 粉末
• 折射率: 1.565
• 储存条件: 室温

牛磺胆酸靶点实验

查看更多实验

实验名称：TP_TRANSPORTER: Western (protein level: increase to 230 %) in vivo, liver of Him OF1 ... 来源：ChEMBL 靶标：ATP-dependent translocase ABCB1 External Id：CHEMBL2077396

实验名称：TP_TRANSPORTER: RT-PCR (mRNA level: a 4-fold increase) in vivo, liver of Him OF1 mous... 来源：ChEMBL 靶标：ATP-dependent translocase ABCB1 External Id：CHEMBL2077398

实验名称：TP_TRANSPORTER: inhibition of Gadoxetate uptake (Gadoxetate: 100 uM, TCA: 200 uM) in ... 来源：ChEMBL 靶标：Solute carrier organic anion transporter family member 1A1 External Id：CHEMBL2076399

实验名称：TP_TRANSPORTER: inhibition of Ochratoxin A uptake (OTA: 1 uM, TCA: 100uM) in Xenopus ... 来源：ChEMBL 靶标：Solute carrier organic anion transporter family member 1A1 External Id：CHEMBL2076389

实验名称：TP_TRANSPORTER: inhibition of LTC4 uptake (LTC4: 0.01uM, Taurocholate: 250 uM) in Xen... 来源：ChEMBL 靶标：Solute carrier organic anion transporter family member 1A1 External Id：CHEMBL2076394

实验名称：Increase the activity of the Burkholderia fixLJ 2-component system 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Burkholderia multivorans External Id：HMS1625

实验名称：TP_TRANSPORTER: uptake in Oatp1-expressing CHO cells 来源：ChEMBL 靶标：Solute carrier organic anion transporter family member 1A1 External Id：CHEMBL2076357

实验名称：TP_TRANSPORTER: inhibition of E1S uptake by Taurocholate at a concentration of 30uM i... 来源：ChEMBL 靶标：Broad substrate specificity ATP-binding cassette transporter ABCG2 External Id：CHEMBL2075603

实验名称：TP_TRANSPORTER: inhibition of benzylpenicillin uptake by Taurocholate at a concentrat... 来源：ChEMBL 靶标：Solute carrier family 22 member 8 External Id：CHEMBL2077332

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

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牛磺胆酸英文别名

• 2-[[(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]ethanesulfonic acid
• Cholyltaurine
• EINECS 201-336-2