人参炔醇

• 常用名: 人参炔醇
• 英文名: (S)-Falcarinol
• CAS号: 81203-57-8
• 分子量: 244.37200
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₇H₂₄O
• 熔点: N/A
• 闪点: N/A

人参炔醇用途

(S)-Falcarinol (Panaxynol),人参中主要的聚乙炔之一,具有抗肿瘤活性。(S)-Falcarinol (Panaxynol) 是人参中最有效的抗血小板药物,其作用机制主要是抑制血栓素的形成。(S)-Falcarinol (Panaxynol) 是有效的 Nrf2 激活剂。

人参炔醇名称

• 中文名: 人参炔醇
• 英文名: (S,Z)-heptadeca-1,9-dien-4,6-diyne-3-ol

人参炔醇生物活性

• 描述: (S)-Falcarinol (Panaxynol),人参中主要的聚乙炔之一,具有抗肿瘤活性。(S)-Falcarinol (Panaxynol) 是人参中最有效的抗血小板药物,其作用机制主要是抑制血栓素的形成。(S)-Falcarinol (Panaxynol) 是有效的 Nrf2 激活剂。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> NF-κB信号通路 >> KEAP1-Nrf2
  研究领域 >> 心血管疾病
• 靶点实验:

  Nrf2[3]

• 参考文献:

  [1]. Mayer SF, et al. Chemoenzymatic asymmetric total syntheses of antitumor agents (3R,9R,10R)- and (3S,9R,10R)-Panaxytriol and (R)- and (S)-Falcarinol from Panax ginseng using an enantioconvergent enzyme-triggered cascade reaction. J Org Chem. 2002 Dec 27;67(26):9115-21.

  [2]. Teng CM,et al. Antiplatelet actions of panaxynol and ginsenosides isolated from ginseng. Biochim Biophys Acta. 1989 Mar 24;990(3):315-20.

  [3]. Qu C, et al. Identifying panaxynol, a natural activator of nuclear factor erythroid-2 related factor 2 (Nrf2) from American ginseng as a suppressor of inflamed macrophage-induced cardiomyocyte hypertrophy. J Ethnopharmacol. 2015 Jun 20;168:326-36.

人参炔醇物理化学性质

• 分子式: C₁₇H₂₄O
• 分子量: 244.37200
• 精确质量: 244.18300
• PSA: 20.23000
• LogP: 3.84690
• InChIKey: UGJAEDFOKNAMQD-MQNTZWLQSA-N
• SMILES: C=CC(O)C#CC#CCC=CCCCCCCC

人参炔醇靶点实验

查看更多实验

实验名称：Antimycobacterial activity against Mycobacterium tuberculosis at 20 ug/disk by disk d... 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL956959

实验名称：Antimycobacterial activity against isoniazid-resistant Mycobacterium avium at 20 ug/d... 来源：ChEMBL 靶标：Mycobacterium avium External Id：CHEMBL956962

实验名称：Antimycobacterial activity against isoniazid-resistant Mycobacterium avium at 100 ug/... 来源：ChEMBL 靶标：Mycobacterium avium External Id：CHEMBL956961

实验名称：Toxicity in Artemia salina after 24 hrs 来源：ChEMBL 靶标：Artemia salina External Id：CHEMBL965114

实验名称：Antimicrobial activity against Pseudomonas aeruginosa K799 by twofold serial microbro... 来源：ChEMBL 靶标：Pseudomonas aeruginosa External Id：CHEMBL984928

实验名称：Antimicrobial activity against Escherichia coli UB1005 by twofold serial microbroth d... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL984927

实验名称：Antimicrobial activity against methicillin-resistant Staphylococcus aureus SAP00017 b... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL984930

实验名称：Antimicrobial activity against Pseudomonas aeruginosa Z61 by twofold serial microbrot... 来源：ChEMBL 靶标：Pseudomonas aeruginosa External Id：CHEMBL984929

实验名称：Antimicrobial activity against Escherichia coli DC2 by twofold serial microbroth dilu... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL984926

实验名称：Cytotoxicity against human NCI60 cells 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL994594

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人参炔醇英文别名

• (S)-Panaxynol
• (3S)-falcarinol
• (S)-Falcarinol
• (+)-falcarinol
• S-falcarinol
• 3S-falcarinol
• (Z)-(S)-Heptadeca-1,9-diene-4,6-diyn-3-ol