7-氯-4-(1-哌嗪基)喹啉

• 常用名: 7-氯-4-(1-哌嗪基)喹啉
• 英文名: 7-Chloro-4-(piperazin-1-yl)quinoline
• CAS号: 837-52-5
• 分子量: 247.72300
• 密度: 1.257 g/cm3
• 沸点: 433.5ºC at 760 mmHg
• 分子式: C₁₃H₁₄ClN₃
• 熔点: 113-116ºC
• 闪点: 216ºC

7-氯-4-(1-哌嗪基)喹啉用途

7-氯-4-(哌嗪-1-基)喹诺酮类药物是一种重要的药物化学支架。7-氯-4-(哌嗪-1-基)喹诺酮类药物是一种有效的sirtuin抑制剂,并可抑制5-羟色胺摄取(IC50为50μM)。7-氯-4-(哌嗪-1-基)喹诺酮类药物对P。IC50分别为1.18μM和0.97μM的恶性疟原虫[1]。

7-氯-4-(1-哌嗪基)喹啉名称

• 中文名: 7-氯-4-(1-哌嗪基)喹啉
• 英文名: 7-Chloro-4-(piperazin-1-yl)quinoline
• 中文别名: 7-氯-4-哌嗪-1-基喹啉 | 7-氯-4-哌嗪基喹啉

7-氯-4-(1-哌嗪基)喹啉生物活性

• 描述: 7-氯-4-(哌嗪-1-基)喹诺酮类药物是一种重要的药物化学支架。7-氯-4-(哌嗪-1-基)喹诺酮类药物是一种有效的sirtuin抑制剂,并可抑制5-羟色胺摄取(IC50为50μM)。7-氯-4-(哌嗪-1-基)喹诺酮类药物对P。IC50分别为1.18μM和0.97μM的恶性疟原虫[1]。
• 相关类别:
  信号通路 >> 表观遗传学 >> 抗衰老酶
  研究领域 >> 感染
  信号通路 >> 细胞周期/DNA损伤 >> 抗衰老酶
• 参考文献:

  [1]. Aida M Abd El-Sattar El-Azzouny, et al. Structural and biological survey of 7-chloro-4-(piperazin-1-yl)quinoline and its derivatives. Drug Dev Res. 2020 Nov;81(7):786-802.

7-氯-4-(1-哌嗪基)喹啉物理化学性质

• 密度: 1.257 g/cm3
• 沸点: 433.5ºC at 760 mmHg
• 熔点: 113-116ºC
• 分子式: C₁₃H₁₄ClN₃
• 分子量: 247.72300
• 闪点: 216ºC
• 精确质量: 247.08800
• PSA: 28.16000
• LogP: 2.69160
• InChIKey: DNXNPMDUDGUXOB-UHFFFAOYSA-N
• SMILES: Clc1ccc2c(N3CCNCC3)ccnc2c1
• 外观性状: 淡黄色固体
• 折射率: 1.636
• 储存条件: 2-8°C

7-氯-4-(1-哌嗪基)喹啉MSDS

7-氯-4-(1-哌嗪基)喹啉MSDS英文版

7-氯-4-(1-哌嗪基)喹啉安全信息

• 危害码 (欧洲): C: Corrosive;
• 风险声明 (欧洲): R34
• 安全声明 (欧洲): S22-S26-S36/37/39-S45
• 海关编码: 2933990090

7-氯-4-(1-哌嗪基)喹啉海关

• 海关编码: 2933990090
• 中文概述: 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

7-氯-4-(1-哌嗪基)喹啉靶点实验

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实验名称：Cytotoxicity against human HeLa cells after 7 days by MTT assay 来源：ChEMBL 靶标：HeLa External Id：CHEMBL1772871

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实验名称：Cytotoxicity against human resting lymphocytes after 3 days by MTT assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL1772872

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Resistance index, ratio of IC50 for chloroquine-resistant Plasmodium falciparum Dd2 t... 来源：ChEMBL 靶标：Plasmodium falciparum External Id：CHEMBL1772874

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7-氯-4-(1-哌嗪基)喹啉英文别名

• 7-chloro-4-piperazin-1-ylquinoline