氟骨三醇

• 常用名: 氟骨三醇
• 英文名: Falecalcitriol
• CAS号: 83805-11-2
• 分子量: 524.579
• 密度: 1.2±0.1 g/cm3
• 沸点: 576.9±50.0 °C at 760 mmHg
• 分子式: C₂₇H₃₈F₆O₃
• 熔点: N/A
• 闪点: 302.7±30.1 °C

氟骨三醇用途

Falecalcitriol(Fulstan; Hornel)是骨化三醇类似物,在体内有更高更长久的活性。

氟骨三醇名称

• 中文名: 氟骨三醇
• 英文名: (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-7,7,7-trifluoro-6-hydroxy-6-(trifluoromethyl)heptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol

氟骨三醇生物活性

• 描述: Falecalcitriol(Fulstan; Hornel)是骨化三醇类似物,在体内有更高更长久的活性。
• 相关类别:
  信号通路 >> 维生素 D 相关 >> VD/VDR
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Ito H, Ogata H, Yamamoto M, Takahashi K, Shishido K, Takahashi J, Taguchi S, Kinugasa E. Comparison of oral falecalcitriol and intravenous calcitriol in hemodialysis patients with secondary hyperparathyroidism: a randomized, crossover trial. Clin Nephro

  [2]. Tokunaga M, Tamura M, Kabashima N, Serino R, Shibata T, Matsumoto M, Miyamoto T, Miyazaki M, Furuno Y, Takeuchi M, Abe H, Okazaki M, Otsuji Y. Falecalcitriol for conventional vitamin D therapy-resistant secondary hyperparathyroidism in a continuous ambul

  [3]. Iwao Y, Yamaguchi Y, Fujii K, Toba Y, Asada M, Nagano N, Yamamoto H, Hyoma K, Yamada S, Hirano H, Tone Y, Ohtani H, Saika Y, Fujii R. Long-term suppressive effect of falecalcitriol on parathyroid hormone secretion in secondary hyperparathyroidism in hemo

  [4]. Morii H. Falecalcitriol as a new therapeutic agent for secondary hyperparathyroidismClin Calcium. 2005 Jan;15(1):29-33.

  [5]. Ohtsuka N, Urayama K. Pharmacological action and clinical effects of falecalcitriol, a highly potent derivative of active vitamin D3.Nihon Yakurigaku Zasshi. 2002 Dec;120(6):427-36.

  [6]. Jean-Pierre Bégué, Danièle Bonnet-Delpon.Recent advances (1995-2005) in fluorinated pharmaceuticals based on natural products. Journal of Fluorine Chemistry.Volume 127, Issue 8, August 2006, Pages 992-1012

氟骨三醇物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 576.9±50.0 °C at 760 mmHg
• 分子式: C₂₇H₃₈F₆O₃
• 分子量: 524.579
• 闪点: 302.7±30.1 °C
• 精确质量: 524.272522
• PSA: 60.69000
• LogP: 7.87
• InChIKey: XPYGGHVSFMUHLH-UUSULHAXSA-N
• SMILES: C=C1C(=CC=C2CCCC3(C)C2CCC3C(C)CCCC(O)(C(F)(F)F)C(F)(F)F)CC(O)CC1O
• 蒸汽压: 0.0±3.6 mmHg at 25°C
• 折射率: 1.505
• 储存条件: 2-8℃

氟骨三醇毒性和生态

氟骨三醇靶点实验

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氟骨三醇英文别名

• Falecalcitriol
• ST-630
• (+)-(5Z,7E)-26,26,26,27,27,27-Hexafluoro-9,10-secocholesta-5,7,10(19)-triene-1a,3b,25-triol
• Hornel
• Fulstan
• Ro 23-4194
• (1S,3R,5Z,7E)-26,26,26,27,27,27-Hexafluoro-9,10-secocholesta-5,7,10-triene-1,3,25-triol
• Hexafluorocalcitriol
• Hornel,Fulstan
• Flocalcitriol
• calcitriol hexafluoride