GNF-7

• 常用名: GNF-7
• 英文名: GNF-7
• CAS号: 839706-07-9
• 分子量: 547.531
• 密度: 1.4±0.1 g/cm3
• 沸点: N/A
• 分子式: C₂₈H₂₄F₃N₇O₂
• 熔点: N/A
• 闪点: N/A

GNF-7用途

GNF-7 抑制 Bcr-Abl WT 和 Bcr-Abl T315I, IC50 分别为133 nM 和 61 nM。

GNF-7名称

• 中文名: GNF-7
• 英文名: N-[4-methyl-3-[1-methyl-7-[(6-methylpyridin-3-yl)amino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-3-yl]phenyl]-3-(trifluoromethyl)benzamide

GNF-7生物活性

• 描述: GNF-7 抑制 Bcr-Abl WT 和 Bcr-Abl T315I, IC50 分别为133 nM 和 61 nM。
• 相关类别:
  信号通路 >> 蛋白酪氨酸激酶 >> BCR-ABL
  研究领域 >> 癌症
• 参考文献:

  [1]. Choi HG, et al. A type-II kinase inhibitor capable of inhibiting the T315I "gatekeeper" mutant of Bcr-Abl. J Med Chem. 2010 Aug 12;53(15):5439-48.

  [2]. Lu X, et al. Hybrid pyrimidine alkynyls inhibit the clinically resistance related Bcr-Abl(T315I) mutant. Bioorg Med Chem Lett. 2015 Sep 1;25(17):3458-63.

  [3]. Liang X, et al. Discovery of 2-((3-Amino-4-methylphenyl)amino)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-ABL-053) as a Potent, Selective, and Orally Available BCR-ABL/SRC/p38 Kinase Inhibitor for Ch

GNF-7物理化学性质

• 密度: 1.4±0.1 g/cm3
• 分子式: C₂₈H₂₄F₃N₇O₂
• 分子量: 547.531
• 精确质量: 547.194336
• PSA: 106.84000
• LogP: 2.78
• InChIKey: SZNYUUZOQHNEKB-UHFFFAOYSA-N
• SMILES: Cc1ccc(Nc2ncc3c(n2)N(C)C(=O)N(c2cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc2C)C3)cn1
• 外观性状: white solid
• 折射率: 1.655
• 储存条件: -20℃

GNF-7靶点实验

查看更多实验

实验名称：Inhibition of SARS-CoV-2-induced cytopathy was measured 4 days after infection of EGF... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL5303712

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

实验名称：Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS-CoV-2-PP

实验名称：Inhibition of Bcr-Abl T315I mutant 来源：ChEMBL 靶标：Tyrosine-protein kinase ABL1 External Id：CHEMBL1217379

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i... 来源：NCGC External Id：NSD2-synergy-p-2C

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i... 来源：NCGC External Id：NSD2-synergy-p-9B

实验名称：Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant ... 来源：NCGC External Id：s-sky_synergy-MV-411_DR-CTG72-MIPE_NPC_NPACT_Kinase-p1

实验名称：Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) naive MV4-11 ce... 来源：NCGC External Id：s-sky_synergy-MV-411_N-CTG72-MIPE_NPC_NPACT_Kinase-p1

实验名称：Primary qHTS for Inhibitors of N-terminal methyltransferase 1 (NTMT1): MTaseGlo Assay 来源：NCGC External Id：NTMT1-p-MTaseGlo

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GNF-7英文别名

• N-(4-Methyl-3-{1-methyl-7-[(6-methyl-3-pyridinyl)amino]-2-oxo-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2H)-yl}phenyl)-3-(trifluoromethyl)benzamide
• 2H-1,4-Benzothiazine,urea deriv.
• GNF-7