乙酯利血平

• 常用名: 乙酯利血平
• 英文名: Syrosingopine
• CAS号: 84-36-6
• 分子量: 666.71500
• 密度: 1.35g/cm3
• 沸点: 795ºC at 760 mmHg
• 分子式: C₃₅H₄₂N₂O₁₁
• 熔点: 175ºC
• 闪点: 434.6ºC

乙酯利血平用途

Syrosingopine (Su 3118) 是一种抗高血压药物。Syrosingopine 能降低多巴胺的水平。

乙酯利血平名称

• 中文名: 乙酯利血平
• 英文名: methyl (1R,15S,17R,18R,19S,20S)-17-(4-ethoxycarbonyloxy-3,5-dimethoxybenzoyl)oxy-6,18-dimethoxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate
• 中文别名: 昔可平 | 昔洛舍平

乙酯利血平生物活性

• 描述: Syrosingopine (Su 3118) 是一种抗高血压药物。Syrosingopine 能降低多巴胺的水平。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> 其他 >> 其他
• 体外研究: 辛罗西平使癌细胞对二甲双胍致敏[1]。
• 参考文献:

  [1]. Benjamin D, et al. Syrosingopine sensitizes cancer cells to killing by metformin. Sci Adv. 2016 Dec 23;2(12):e1601756.

  [2]. Furukawa T, et al. Selective depleting effect of syrosingopine on brain catecholamine levels with relation to morphine analgesia in the rat. Pharmacol Biochem Behav. 1976 Apr;4(4):419-25.

乙酯利血平物理化学性质

• 密度: 1.35g/cm3
• 沸点: 795ºC at 760 mmHg
• 熔点: 175ºC
• 分子式: C₃₅H₄₂N₂O₁₁
• 分子量: 666.71500
• 闪点: 434.6ºC
• 精确质量: 666.27900
• PSA: 144.08000
• LogP: 4.63570
• InChIKey: ZCDNRPPFBQDQHR-SSYATKPKSA-N
• SMILES: CCOC(=O)Oc1c(OC)cc(C(=O)OC2CC3CN4CCc5c([nH]c6cc(OC)ccc56)C4CC3C(C(=O)OC)C2OC)cc1OC
• 外观性状: 白色至浅棕色粉末
• 折射率: 1.615
• 储存条件: 室温，干燥，避光
• 水溶解性: Insuluble (3.1E-4 g/L) (25 ºC)

乙酯利血平毒性和生态

乙酯利血平安全信息

• 危害码 (欧洲): Xn
• 危险品运输编码: UN 1544
• 包装等级: III
• 危险类别: 6.1(b)

乙酯利血平靶点实验

查看更多实验

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

实验名称：MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Activator_SinglePoint... 来源：Broad Institute 靶标：N/A External Id：2084-01_Activator_SinglePoint_HTS_Activity

实验名称：Counterscreen for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberc... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：GDH-TPI_INH_ABS_1536_1X%INH CSRUN

实验名称：qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity 来源：NCGC External Id：HERG01

实验名称：qHTS for Inhibitors of TGF-b: Cytotox Counterscreen 来源：NCGC 靶标：N/A External Id：SMAD3201

实验名称：uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay 来源：Burnham Center for Chemical Genomics 靶标：cystic fibrosis transmembrane conductance regulator [Homo sapiens] External Id：SBCCG-A764-CF-PAF-Primary-Assay

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ant... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_ANT_FLUO8_1536_1X%INH PRUN

共202条，当前第1页，共21页

1

2

3

4

5

乙酯利血平英文别名

• syrosingopine
• Etropres
• EINECS 201-527-0
• Syrosingopin
• Isotense
• Menatensina
• Novoserpina
• Neoreserpan
• Elufinesin
• Vegaserpina
• Syringopine
• MFCD00017411