84-36-6

• 常用中文名：乙酯利血平
• 常用英文名：Syrosingopine
• CAS号：84-36-6
• 分子式：C₃₅H₄₂N₂O₁₁
• 分子量：666.71500
• 相关类别： 天然产物 生物碱
• 发布时间：2018-06-03 08:00:00
• 更新时间：2024-01-03 18:51:51
• Syrosingopine (Su 3118) 是一种抗高血压药物。Syrosingopine 能降低多巴胺的水平。

名称

• 中文名: 乙酯利血平
• 英文名: methyl (1R,15S,17R,18R,19S,20S)-17-(4-ethoxycarbonyloxy-3,5-dimethoxybenzoyl)oxy-6,18-dimethoxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate
• 中文别名: 昔可平; 昔洛舍平
• 英文别名: syrosingopine; Etropres; EINECS 201-527-0; Syrosingopin; Isotense; Menatensina; Novoserpina; Neoreserpan; Elufinesin; Vegaserpina; Syringopine; MFCD00017411

物化性质

• 密度: 1.35g/cm3
• 沸点: 795ºC at 760 mmHg
• 熔点: 175ºC
• 分子式: C₃₅H₄₂N₂O₁₁
• 分子量: 666.71500
• 闪点: 434.6ºC
• 精确质量: 666.27900
• PSA: 144.08000
• LogP: 4.63570
• 外观性状: 白色至浅棕色粉末
• 折射率: 1.615
• 储存条件: 室温，干燥，避光
• 水溶解性: Insuluble (3.1E-4 g/L) (25 ºC)

生物活性

• 描述: Syrosingopine (Su 3118) 是一种抗高血压药物。Syrosingopine 能降低多巴胺的水平。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> 其他 >> 其他
• 体外研究: 辛罗西平使癌细胞对二甲双胍致敏[1]。
• 参考文献:

  [1]. Benjamin D, et al. Syrosingopine sensitizes cancer cells to killing by metformin. Sci Adv. 2016 Dec 23;2(12):e1601756.

  [2]. Furukawa T, et al. Selective depleting effect of syrosingopine on brain catecholamine levels with relation to morphine analgesia in the rat. Pharmacol Biochem Behav. 1976 Apr;4(4):419-25.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : ZG0175000 CHEMICAL NAME : 3-beta,20-alpha-Yohimban-16-beta-carboxylic acid, 18-beta-hydroxy-11,17-alpha-dimethoxy-, methyl ester, ester with 4-hydroxy-3,5-dimethoxybenzoic acid ethyl carbonate CAS REGISTRY NUMBER : 84-36-6 LAST UPDATED : 199610 DATA ITEMS CITED : 9 MOLECULAR FORMULA : C35-H42-N2-O11 MOLECULAR WEIGHT : 666.79 WISWESSER LINE NOTATION : T F6 D5 C666 EM ON&&TTTJ HO1 SOVR CO1 EO1 DOVO2& TO1 UVO1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,386,1975 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 286 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,365,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,386,1975 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 119,245,1959 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1293 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,365,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 101 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,365,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 281 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,365,1982 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 10 mg/kg SEX/DURATION : female 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - other measures of fertility REFERENCE : ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 78,225,1966 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported DOSE : 10 mg/kg SEX/DURATION : female 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - other measures of fertility REFERENCE : AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 83,1405,1962

安全

• 危害码 (欧洲): Xn
• 危险品运输编码: UN 1544
• 包装等级: III
• 危险类别: 6.1(b)

合成路线

18780-68-2 2901-66-8 ~% 84-36-6

文献：US2813871 , ;