7,3',5'-三羟基黄烷酮

• 常用名: 7,3',5'-三羟基黄烷酮
• 英文名: 7,3′,5′-Trihydroxyflavanone
• CAS号: 847375-46-6
• 分子量: 272.253
• 密度: 1.5±0.1 g/cm3
• 沸点: 580.1±50.0 °C at 760 mmHg
• 分子式: C₁₅H₁₂O₅
• 熔点: N/A
• 闪点: 225.8±23.6 °C

7,3',5'-三羟基黄烷酮用途

类黄烷衍生物7,3′,5′-三羟基黄烷酮通过增加Bax表达水平诱导MCF-7细胞凋亡。7,3′,5′-三羟基黄烷酮也具有抗氧化活性[1][2]。

7,3',5'-三羟基黄烷酮名称

• 中文名: 7,3',5'-三羟基黄烷酮
• 英文名: 7,3',5'-trihydroxyflavanone

7,3',5'-三羟基黄烷酮生物活性

• 描述: 类黄烷衍生物7,3′,5′-三羟基黄烷酮通过增加Bax表达水平诱导MCF-7细胞凋亡。7,3′,5′-三羟基黄烷酮也具有抗氧化活性[1][2]。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
• 参考文献:

  [1]. Abdullah H, et, al. A natural compound from Hydnophytum formicarium induces apoptosis of MCF-7 cells via up-regulation of Bax. Cancer Cell Int. 2010 May 4;10:14.

  [2]. Tsvetkov DE, et, al. Components of the extracts of the knot wood of Dalbergia Sissoo Linn. and their antioxidant activity. Russian Chemical Bulletin. 2019 Sep; 68:1756-1762.

7,3',5'-三羟基黄烷酮物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 580.1±50.0 °C at 760 mmHg
• 分子式: C₁₅H₁₂O₅
• 分子量: 272.253
• 闪点: 225.8±23.6 °C
• 精确质量: 272.068481
• LogP: 2.04
• InChIKey: OVSYWZXDPOVKQU-AWEZNQCLSA-N
• SMILES: O=C1CC(c2cc(O)cc(O)c2)Oc2cc(O)ccc21
• 蒸汽压: 0.0±1.7 mmHg at 25°C
• 折射率: 1.693

7,3',5'-三羟基黄烷酮靶点实验

查看更多实验

实验名称：Inhibition of recombinant human PTP1B using p-nitrophenyl phosphate as substrate at 1... 来源：ChEMBL 靶标：Tyrosine-protein phosphatase non-receptor type 1 External Id：CHEMBL4035961

实验名称：Inhibition of LPS-induced NF-kappaB transcription (unknown origin) expressed in human... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4035959

实验名称：Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induc... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL4035957

实验名称：Activation of Nrf2 (unknown origin) expressed in human HepG2 cells at 10 uM incubated... 来源：ChEMBL 靶标：Nuclear factor erythroid 2-related factor 2 External Id：CHEMBL4046717

实验名称：Growth inhibition of human HepG2 cells at 10 uM after 24 hrs by MTS assay relative to... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4035954

实验名称：Growth inhibition of human MCF7 cells at 10 uM after 24 hrs by MTS assay relative to ... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL4035952

实验名称：Growth inhibition of human SW480 cells at 10 uM after 24 hrs by MTS assay relative to... 来源：ChEMBL 靶标：SW480 External Id：CHEMBL4035953

实验名称：Inhibition of mushroom tyrosinase at 10 uM using L-tyrosine as substrate incubated fo... 来源：ChEMBL 靶标：Polyphenol oxidase 4 External Id：CHEMBL4035963

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7,3',5'-三羟基黄烷酮英文别名

• (2S)-2-(3,5-Dihydroxyphenyl)-2,3-dihydro-7-hydroxy-4H-1-benzopyran-4-one