阿格列汀苯甲酸盐

• 常用名: 阿格列汀苯甲酸盐
• 英文名: Alogliptin benzoate
• CAS号: 850649-62-6
• 分子量: 461.513
• 密度: N/A
• 沸点: 671.2ºC at 760 mmHg
• 分子式: C₂₅H₂₇N₅O₄
• 熔点: N/A
• 闪点: 359.7ºC

阿格列汀苯甲酸盐用途

Alogliptin benzoate(SYR 322)是高活性DPP-4抑制剂,IC50<10 nM,比对DPP-8和DPP-9的抑制性高10000倍。

阿格列汀苯甲酸盐名称

• 中文名: 2-[[6-[(3R)-3-氨基-1-哌啶基]-3,4-二氢-3-甲基-2,4-二氧代-1(2H)-嘧啶基]甲基]苯甲腈苯甲酸盐
• 英文名: alogliptin benzoate
• 中文别名: 苯甲酸阿格利汀 | 苯甲酸阿格列汀 | 阿格列汀苯甲酸盐 | 苯甲酸盐阿格列汀

阿格列汀苯甲酸盐生物活性

• 描述: Alogliptin benzoate(SYR 322)是高活性DPP-4抑制剂,IC50<10 nM,比对DPP-8和DPP-9的抑制性高10000倍。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 二肽基肽酶
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Rendell M, et al. Alogliptin benzoate for the treatment of type 2 diabetes. Expert Opin Pharmacother. 2012 Mar;13(4):553-63.

  [2]. Radha Andukuri, et al. Alogliptin: a new addition to the class of DPP-4 inhibitors. Diabetes Metab Syndr Obes. 2009; 2: 117-126.

  [3]. Takeuchi K, et al. Pharmacological and clinical profile of alogliptin benzoate (NESINA?).Nihon Yakurigaku Zasshi. 2011 Jan;137(1):43-50.

  [4]. Moritoh Y, et al. Chronic administration of alogliptin, a novel, potent, and highly selective dipeptidyl peptidase-4 inhibitor, improves glycemic control and beta-cell function in obese diabetic ob/ob mice.Eur J Pharmacol. 2008 Jul 7;588(2-3):325-32.

阿格列汀苯甲酸盐物理化学性质

• 沸点: 671.2ºC at 760 mmHg
• 分子式: C₂₅H₂₇N₅O₄
• 分子量: 461.513
• 闪点: 359.7ºC
• 精确质量: 461.206299
• PSA: 134.35000
• LogP: 2.54458
• InChIKey: KEJICOXJTRHYAK-XFULWGLBSA-N
• SMILES: Cn1c(=O)cc(N2CCCC(N)C2)n(Cc2ccccc2C#N)c1=O.O=C(O)c1ccccc1
• 外观性状: 白色-黄色 粉末
• 储存条件: 室温

阿格列汀苯甲酸盐靶点实验

查看更多实验

实验名称：Oral bioavailability in monkey 来源：ChEMBL 靶标：Macaca mulatta External Id：CHEMBL1023110

实验名称：Bioavailability in monkey at 1.1 mg/kg, iv and 10 mg/kg, po 来源：ChEMBL 靶标：Macaca mulatta External Id：CHEMBL916130

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

实验名称：Enzymatic assay of human HDAC6 with custom peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808150

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Half life in monkey at 10 mg/kg, po 来源：ChEMBL 靶标：Macaca mulatta External Id：CHEMBL916126

实验名称：AUC in monkey at 10 mg/kg, po 来源：ChEMBL 靶标：Macaca mulatta External Id：CHEMBL916127

实验名称：Clearance in monkey at 1.1 mg/kg, iv and 10 mg/kg, po 来源：ChEMBL 靶标：Macaca mulatta External Id：CHEMBL916128

实验名称：Volume of distribution at steady state in monkey at 1.1 mg/kg, iv and 10 mg/kg, po 来源：ChEMBL 靶标：Macaca mulatta External Id：CHEMBL916129

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

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阿格列汀苯甲酸盐英文别名

• Benzonitrile, 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-, benzoate (1:1)
• 2-[[6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxopyrimidin-1-yl]methyl]benzonitrile,benzoic acid
• SYR 322
• Vipidia (TN)
• Alogliptin (Benzoate)
• Alogliptin benzoate
• 2-({6-[(3R)-3-Amino-1-piperidinyl]-3-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl}methyl)benzonitrile benzoate (1:1)
• 2-({6-[(3R)-3-Aminopiperidin-1-yl]-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl}methyl)benzonitrile benzoate (1:1)
• alogliptin monobenzoate
• Nesina
• 2-[6-[3(R)-Aminopiperidin-1-yl]-3-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-ylmethyl]benzonitrile benzoate