KR-32568

更新时间：2025-08-25 18:46:08

KR-32568结构式	常用名	KR-32568	英文名	KR-32568
	CAS号	852146-73-7	分子量	261.25200
	密度	1.38g/cm3	沸点	444.1ºC at 760 mmHg
	分子式	C₁₃H₁₂FN₃O₂	熔点	N/A
	MSDS	中文版美版	闪点	222.4ºC
	符号	GHS07	信号词	Warning

KR-32568用途

KR-32568是一种钠/氢交换剂-1(NHE-1)抑制剂,IC50为230nM。KR-32568具有心脏保护作用[1][2]。

英文名	N-(diaminomethylidene)-5-(5-fluoro-2-methylphenyl)furan-2-carboxamide
英文别名	更多

描述	KR-32568是一种钠/氢交换剂-1(NHE-1)抑制剂,IC50为230nM。KR-32568具有心脏保护作用[1][2]。
相关类别	研究领域 >> 心血管疾病
靶点实验	IC50: 230 nM (NHE-1)[2]
体外研究	KR-32568(10 nM-1μM)以浓度依赖性方式抑制 NHE-1型介导的兔富血小板血浆细胞内酸化引起的血小板肿胀,国际50值为 24nM[1]
体内研究	KR-32568(0.1-1.0mg/kg；静脉注射一次)对大鼠发挥有效的心脏保护作用,例如减少梗塞面积,并显着减少室性早搏的总数[1]。动物模型：雄性Sprague-Dawley大鼠(350-380 g)承受30分钟缺血/2.5小时再灌注心脏损伤[1]剂量：0.1 mg/kg和1.0 mg/kg给药：静脉注射。；结果：在大鼠体内发挥了强大的心脏保护作用。
参考文献	[1]. Hui-Yul Roh, et al. Cardioprotective effects of [5-(2-methyl-5-fluorophenyl)furan-2-ylcarbonyl]guanidine (KR-32568) in an anesthetized rat model of ischemia and reperfusion heart injury. Pharmacology. 2005 Dec;75(1):37-44. [2]. Sunkyung Lee, et al. (5-Arylfuran-2-ylcarbonyl)guanidines as cardioprotectives through the inhibition of Na+/H+ exchanger isoform-1. J Med Chem. 2005 Apr 21;48(8):2882-91.

密度	1.38g/cm3
沸点	444.1ºC at 760 mmHg
分子式	C₁₃H₁₂FN₃O₂
分子量	261.25200
闪点	222.4ºC
精确质量	261.09100
PSA	92.11000
LogP	3.20830
InChIKey	DTLDHYBZLVASJQ-UHFFFAOYSA-N
SMILES	Cc1ccc(F)cc1-c1ccc(C(=O)N=C(N)N)o1
折射率	1.617
储存条件	-20°C，密闭，干燥

符号	GHS07
信号词	Warning
危害声明	H302-H315-H319-H335
警示性声明	P261-P305 + P351 + P338
个人防护装备	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
危险品运输编码	NONH for all modes of transport

Carbonic anhydrase activation is associated with worsened pathological remodeling in human ischemic diabetic cardiomyopathy.

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Diabetes mellitus (DM) has multifactorial detrimental effects on myocardial tissue. Recently, carbonic anhydrases (CAs) have been shown to play a major role in diabetic microangiopathy but their role ...

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来源：ChEMBL
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External Id：CHEMBL836460

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实验名称：Inhibitory activity against Na+/H+ exchanger 1 (NHE-1) expressed in PS120 cells
来源：ChEMBL
靶标：Sodium/hydrogen exchanger 1
External Id：CHEMBL832458

实验名称：qHTS for Inhibitors of Polymerase Kappa
来源：NCGC
靶标：DNA polymerase kappa [Homo sapiens]
External Id：PolK100

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来源：NCGC
靶标：gene 4 small orf - Marburg virus
External Id：VSVM-OFFLINE

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来源：NCGC
靶标：N/A
External Id：VSVL-OFFLINE

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[5-(2-Methyl-5-fluorophenyl)furan-2-ylcarbonyl]guanidine