Ponesimod

• 常用名: Ponesimod
• 英文名: Ponesimod
• CAS号: 854107-55-4
• 分子量: 460.974
• 密度: 1.3±0.1 g/cm3
• 沸点: 658.0±65.0 °C at 760 mmHg
• 分子式: C₂₃H₂₅ClN₂O₄S
• 熔点: N/A
• 闪点: 351.7±34.3 °C

Ponesimod用途

Ponesimod(ACT-128800)是S1P1受体选择性口服型激动剂。

Ponesimod名称

• 中文名: Ponesimod
• 英文名: (5Z)-5-[[3-chloro-4-[(2R)-2,3-dihydroxypropoxy]phenyl]methylidene]-3-(2-methylphenyl)-2-propylimino-1,3-thiazolidin-4-one

Ponesimod生物活性

• 描述: Ponesimod(ACT-128800)是S1P1受体选择性口服型激动剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> LPL受体
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Piali L, et al. The selective sphingosine 1-phosphate receptor 1 agonist ponesimod protects against lymphocyte-mediated tissue inflammation. J Pharmacol Exp Ther. 2011 May;337(2):547-56.

  [2]. Bolli MH, et al. 2-imino-thiazolidin-4-one derivatives as potent, orally active S1P1 receptor agonists. J Med Chem. 2010 May 27;53(10):4198-211.

  [3]. Brossard P, et al. Pharmacokinetics and pharmacodynamics of ponesimod, a selective S1P1 receptor modulator, in the first-in-human study. Br J Clin Pharmacol. 2013 Dec;76(6):888-96.

Ponesimod物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 658.0±65.0 °C at 760 mmHg
• 分子式: C₂₃H₂₅ClN₂O₄S
• 分子量: 460.974
• 闪点: 351.7±34.3 °C
• 精确质量: 460.122345
• PSA: 107.66000
• LogP: 5.08
• InChIKey: LPAUOXUZGSBGDU-ULCCENQXSA-N
• SMILES: CCCN=C1SC(=Cc2ccc(OCC(O)CO)c(Cl)c2)C(=O)N1c1ccccc1C
• 外观性状: 粉末
• 蒸汽压: 0.0±2.1 mmHg at 25°C
• 折射率: 1.619
• 储存条件: -20℃

Ponesimod靶点实验

查看更多实验

实验名称：Antiinflammatory activity in psoriasis patient assessed as incident of 75% reduction ... 来源：ChEMBL 靶标：Homo sapiens External Id：CHEMBL4266929

实验名称：Human S1P3 receptor (Lysophospholipid (S1P) receptors) 来源：IUPHAR-DB 靶标：S1P3 receptor (Lysophospholipid (S1P) receptors) [Homo sapiens] External Id：277_Human

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Immunomodulatory activity in normotensive Wistar rat assessed as change in circulatin... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1108349

实验名称：Immunomodulatory activity in normotensive Wistar rat assessed as change in circulatin... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1108348

实验名称：Immunomodulatory activity in normotensive Wistar rat assessed as change in circulatin... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1108347

实验名称：Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgamm... 来源：ChEMBL 靶标：Sphingosine 1-phosphate receptor 3 External Id：CHEMBL1108346

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

实验名称：Agonist activity at human recombinant S1P1 receptor expressed in CHO cells by GTPgamm... 来源：ChEMBL 靶标：Sphingosine 1-phosphate receptor 1 External Id：CHEMBL1108345

实验名称：Enzymatic assay of human HDAC6 with custom peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808150

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Ponesimod英文别名

• UNII-5G7AKV2MKP
• Ponesimod
• (2Z,5Z)-5-{3-Chloro-4-[(2R)-2,3-dihydroxypropoxy]benzylidene}-3-(2-methylphenyl)-2-(propylimino)-1,3-thiazolidin-4-one
• ACT-128800