Indirubin Derivative E804

• 常用名: Indirubin Derivative E804
• 英文名: Indirubin E804
• CAS号: 854171-35-0
• 分子量: 365.38
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₁₉N₃O₄
• 熔点: N/A
• 闪点: N/A

Indirubin Derivative E804用途

Indirubin Derivative E804, 是类胰岛素生长因子1型受体 (IGF1R) 的有效抑制剂,其 IC50 值为 0.65 μM。

Indirubin Derivative E804名称

• 中文名: Indirubin Derivative E804
• 英文名: Indirubin Derivative E804

Indirubin Derivative E804生物活性

• 描述: Indirubin Derivative E804, 是类胰岛素生长因子1型受体 (IGF1R) 的有效抑制剂,其 IC50 值为 0.65 μM。
• 相关类别:
  信号通路 >> 蛋白酪氨酸激酶 >> IGF-1R
  研究领域 >> 癌症
  研究领域 >> 其他
• 靶点实验:

  IC50: 0.65 μM (IGF1R)[1].

• 体外研究: Indirubin Derivative E804是一种水溶性靛玉红衍生物,是胰岛素样生长因子1受体(IGF1R)的有效抑制剂,IC50为0.65μM。 Indirubin Derivative E804也抑制CDK2/CycE,EC50为0.23μM[1]。
• 参考文献:

  [1]. Cheng X, et al. Identification of a Water-Soluble Indirubin Derivative as Potent Inhibitor of Insulin-like Growth Factor 1 Receptor through Structural Modification of the Parent Natural Molecule. J Med Chem. 2017 Jun 22;60(12):4949-4962.

Indirubin Derivative E804物理化学性质

• 分子式: C₂₀H₁₉N₃O₄
• 分子量: 365.38
• InChIKey: TWOSIFOFWWXXIG-PTGBLXJZSA-N
• SMILES: OCC(O)CCON=C1C(c2c(O)[nH]c3ccccc23)=Nc2ccccc21
• 外观性状: 固体
• 储存条件: 2-8°C，密封，干燥

Indirubin Derivative E804靶点实验

查看更多实验

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

实验名称：Millipore: Percentage of residual kinase activity of PRKAA2 at 10uM relative to contr... 来源：ChEMBL 靶标：5'-AMP-activated protein kinase catalytic subunit alpha-1 External Id：CHEMBL2219380

实验名称：Millipore: Percentage of residual kinase activity of NUAK1 at 1uM relative to control... 来源：ChEMBL 靶标：NUAK family SNF1-like kinase 1 External Id：CHEMBL2219381

实验名称：Millipore: Percentage of residual kinase activity of PRKAA1 at 10uM relative to contr... 来源：ChEMBL 靶标：5'-AMP-activated protein kinase catalytic subunit alpha-1 External Id：CHEMBL2219378

实验名称：Millipore: Percentage of residual kinase activity of PRKAA2 at 1uM relative to contro... 来源：ChEMBL 靶标：5'-AMP-activated protein kinase catalytic subunit alpha-1 External Id：CHEMBL2219379

实验名称：Millipore: Percentage of residual kinase activity of MAP3K5 at 10uM relative to contr... 来源：ChEMBL 靶标：Mitogen-activated protein kinase kinase kinase 5 External Id：CHEMBL2218943

实验名称：Millipore: Percentage of residual kinase activity of ABL1 at 1uM relative to control.... 来源：ChEMBL 靶标：Tyrosine-protein kinase ABL1 External Id：CHEMBL2218944

实验名称：Millipore: Percentage of residual kinase activity of NUAK1 at 10uM relative to contro... 来源：ChEMBL 靶标：NUAK family SNF1-like kinase 1 External Id：CHEMBL2219382

实验名称：Millipore: Percentage of residual kinase activity of MAP3K5 at 1uM relative to contro... 来源：ChEMBL 靶标：Mitogen-activated protein kinase kinase kinase 5 External Id：CHEMBL2219383

实验名称：Millipore: Percentage of residual kinase activity of TNK2 at 10uM relative to control... 来源：ChEMBL 靶标：Activated CDC42 kinase 1 External Id：CHEMBL2219372

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