Indirubin E804

Modify Date: 2024-01-03 18:21:45

Indirubin E804 Structure
Indirubin E804 structure
Common Name Indirubin E804
CAS Number 854171-35-0 Molecular Weight 365.38
Density N/A Boiling Point N/A
Molecular Formula C20H19N3O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Indirubin E804


E 804 is a potent inhibitor of Insulin-like Growth Factor 1 Receptor (IGF1R), with an IC50 of 0.65 μM for IGF1R.

 Names

Name Indirubin Derivative E804

 Indirubin E804 Biological Activity

Description E 804 is a potent inhibitor of Insulin-like Growth Factor 1 Receptor (IGF1R), with an IC50 of 0.65 μM for IGF1R.
Related Catalog
Target

IC50: 0.65 μM (IGF1R)[1].

In Vitro Indirubin Derivative E804 is a water-soluble indirubin derivative as potent inhibitor of Insulin-like Growth Factor 1 Receptor (IGF1R), with an IC50 of 0.65 μM. Indirubin Derivative E804 also inhibits CDK2/CycE with an EC50 of 0.23 μM[1].
References

[1]. Cheng X, et al. Identification of a Water-Soluble Indirubin Derivative as Potent Inhibitor of Insulin-like Growth Factor 1 Receptor through Structural Modification of the Parent Natural Molecule. J Med Chem. 2017 Jun 22;60(12):4949-4962.

 Chemical & Physical Properties

Molecular Formula C20H19N3O4
Molecular Weight 365.38
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