Naloxegol

• 常用名: Naloxegol
• 英文名: Naloxegol
• CAS号: 854601-70-0
• 分子量: 651.78500
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₄H₅₃NO₁₁
• 熔点: N/A
• 闪点: N/A

Naloxegol用途

Naloxegol (NKTR-118; AZ-13337019) 是阿片受体拮抗剂。

Naloxegol名称

• 中文名: Naloxegol
• 英文名: naloxegol

Naloxegol生物活性

• 描述: Naloxegol (NKTR-118; AZ-13337019) 是阿片受体拮抗剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 阿片受体
  信号通路 >> 神经信号通路 >> 阿片受体
  研究领域 >> 神经疾病
• 靶点实验:

  Opioid receptor[1]

• 参考文献:

  [1]. Garnock-Jones KP, et al. Naloxegol: a review of its use in patients with opioid-induced constipation. Drugs. 2015 Mar;75(4):419-25.

  [2]. Yoon SC, et al. Naloxegol in opioid-induced constipation: a new paradigm in the treatment of a common problem. Patient Prefer Adherence. 2017 Jul 24;11:1265-1271.

Naloxegol物理化学性质

• 分子式: C₃₄H₅₃NO₁₁
• 分子量: 651.78500
• 精确质量: 651.36200
• PSA: 126.77000
• LogP: 1.80140
• InChIKey: XNKCCCKFOQNXKV-ZRSCBOBOSA-N
• SMILES: C=CCN1CCC23c4c5ccc(O)c4OC2C(OCCOCCOCCOCCOCCOCCOCCOC)CCC3(O)C1C5
• 储存条件: 2-8℃

Naloxegol靶点实验

查看更多实验

实验名称：Antiviral activity against SARS-CoV-2 (USA-WA1/2020 strain) measured by imaging in HR... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303810

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

实验名称：Enzymatic assay of human HDAC6 with custom peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808150

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

实验名称：Primary qHTS for Vero E6 cytotoxicity: counterscreen for inhibitors of SARS-S pseudo-... 来源：NCGC 靶标：N/A External Id：TRND-SARS-cytotox-48hr-p1-npc

实验名称：Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase... 来源：NCGC External Id：GPx1-biochemical-p4-p7

实验名称：Primary qHTS for inhibitors of MERS-S pseudo-typed particle cell entry 来源：NCGC 靶标：N/A External Id：TRND-MERS-PP-p1-npc

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

实验名称：Primary qHTS for Huh7 cytotoxicity: counterscreen for inhibitors of MERS-S pseudotype... 来源：NCGC 靶标：N/A External Id：TRND-MERS-cytotox-48hr-p1-npc

实验名称：Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS-CoV-2-PP

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Naloxegol英文别名

• UNII-44T7335BKE
• NKTR-118
• (4R,4aS,7S,7aR,12bS)-7-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-3-prop-2-enyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diol
• Naloxegol