唑替丁

• 常用名: 唑替丁
• 英文名: Zaltidine
• CAS号: 85604-00-8
• 分子量: 222.27000
• 密度: 1.7g/cm3
• 沸点: 622.9ºC at 760 mmHg
• 分子式: C₈H₁₀N₆S
• 熔点: N/A
• 闪点: 330.5ºC

唑替丁用途

Zaltidine(CP-57361)是H2受体拮抗剂，有抗分泌活性。

唑替丁名称

• 中文名: 唑替丁
• 英文名: 2-[4-(2-methyl-1H-imidazol-5-yl)-1,3-thiazol-2-yl]guanidine

唑替丁生物活性

• 描述: Zaltidine(CP-57361)是H2受体拮抗剂,有抗分泌活性。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体
  信号通路 >> 免疫及炎症 >> 组胺受体
  研究领域 >> 内分泌
• 参考文献:

  [1]. Laferla G, Buchanan N, Hearns J, The antisecretory effects of zaltidine, a novel long-acting H2-receptor antagonist, in healthy volunteers and in subjects with a past history of duodenal ulcer. Br J Clin Pharmacol. 1986 Oct;22(4):395-9.

  [2]. Farup PG. Zaltidine: an effective but hepatotoxic H2-receptor antagonist. Scand J Gastroenterol. 1988 Aug;23(6):655-8.

唑替丁物理化学性质

• 密度: 1.7g/cm3
• 沸点: 622.9ºC at 760 mmHg
• 分子式: C₈H₁₀N₆S
• 分子量: 222.27000
• 闪点: 330.5ºC
• 精确质量: 222.06900
• PSA: 134.21000
• LogP: 2.14710
• InChIKey: GIMNAEMRNXUAQP-UHFFFAOYSA-N
• SMILES: Cc1ncc(-c2csc(N=C(N)N)n2)[nH]1
• 折射率: 1.844
• 储存条件: 2-8℃

唑替丁靶点实验

查看更多实验

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Choleostatic liver toxicity, either proven histopathologically or where the ratio of ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3137727

实验名称：Severe hepatitis, defined as possibly life-threatening liver failure or through clini... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3137728

实验名称：Histamine H2 receptor antagonistic activity was evaluated in guinea pig atrium. 来源：ChEMBL 靶标：Histamine H2 receptor External Id：CHEMBL693347

实验名称：Chronic liver disease either proven histopathologically, or through a chonic elevatio... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3137729

实验名称：Cirrhosis, proven histopathologically. Value is number of references indexed. [column... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3137730

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

实验名称：Granulomatous liver disease, proven histopathologically. Value is number of reference... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3137731

实验名称：Enzymatic assay of human HDAC6 with custom peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808150

实验名称：Liver damage due to vascular disease: peliosis hepatitis, hepatic veno-occlusive dise... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3137732

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唑替丁英文别名

• Zaltidine hydrochloride [USAN]
• Zaltidinum
• Zaltidina
• Zaltidine
• Zaltidine HCl
• Zaltidinum [Latin]
• Zaltidina [Spanish]
• ZALTIDINE HYDROCHLORIDE